
NCBI . NLM . NIH . GOV {
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Title[redir]:
GDF15 Induces Anorexia through Nausea and Emesis - PMC
Description:
Growth differentiation factor 15 (GDF15) is a cytokine that reduces food intake through activation of hindbrain GFRAL-RET receptors and has become a keen target of interest for anti-obesity therapies. Elevated endogenous GDF15 is associated with ...
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Keywords {๐}
gdf, anorexia, rats, weight, pubmed, google, scholar, doi, intake, body, food, kaolin, cisplatin, emesis, data, cat, loss, pmc, nausea, effects, article, cfos, animals, gfral, induced, mice, treatment, gdfinduced, free, administration, figure, mgkg, systemic, levels, measured, cancer, pica, expression, apnts, compared, analyzed, min, signaling, neurons, dose, test, ond, controls, hindbrain, anorectic,
Topics {โ๏ธ}
growth/differentiation factor-15/macrophage-inhibiting cytokine-1 high-fat/high-sucrose diet starโ methods lead contact rabbit anti-fos antibody sheep anti-gfral antibody cisplatin-induced c-fos expression gdf15-induced c-fos distribution pmc beta search gfral receptor-mic-1/gdf15 pathway pre-made master mix c-fos immunoreactive cells tgf-beta superfamily cytokine kool-aid powder [cherry c-fos positive neurons gdf15-induced c-fos activates gfral-expressing neurons cisplatin induced c-fos excitatory hindbrain-forebrain communication attenuating gdf15-induced anorexia precisely interrogate gdf15-gfral dose-dependently induced anorexia hfsd-induced obese rats blunting gdf15-gfral signaling cisplatin-induced gdf15 increases commonly prescribed anti-emetic mic-1/gdf15-gfral pathway free-floating sections published article includes prevent gdf15-induced anorexia pre-designed taqman probes centrally ondansetron pre-treatments reduce gdf15-gfral signaling de jonghe bc growth differentiation factor-15 gfral-ret receptor complex genetic-based targeting approaches modify cisplatin-induced emesis gdf15-gfral-induced anorexia cisplatin-induced gdf15 expression comparable c-fos immunofluorescence show c-fos expression block gdf15-induced anorexia gdf15-gfral induces nausea cisplatin-induced kaolin intake hindbrain gfral-ret receptors reduced chemotherapy-induced malaise food intake-suppressive effects express c-fos 24 blood-brain fluid barriers tgf-beta superfamily
Questions {โ}
- Picaโa model of nausea?
- Why canโt rodents vomit?
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