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Keywords {🔍}

cells, avasimibe, cholesterol, lung, tumor, cancer, kras, doi, kvax, cell, fig, mice, treatment, vaccine, tumors, efficacy, levels, pubmed, google, scholar, increased, model, free, mutant, peptides, lkr, pmc, combined, combination, article, immune, antitumor, metabolism, krasdriven, acat, found, effector, krasla, shown, data, reverse, mouse, flow, ifnγ, results, multipeptide, responses, study, staining, tils,

Topics {✒️}

pe-cy7 anti-tnf-α antibody anti-interferon-γ detection antibody pe-cy7 anti-ly6c ab rafting mhc-ii domains immune-mediated anti-cancer efficacy prevent kras-driven cancers kras-driven lung adenocarcinoma immunotherapy-mediated cancer eradication chronic myelogenous leukemia kras-driven lung tumorigenesis lsr-ii flow cytometer tcr/peptide/mhc interactions beneficial anti-tumor effects fixable live/dead dye pe anti-ifn-γ improved anti-cancer efficacy pe-cy7 anti-cd44 multi-peptide kras vaccine kras multi-peptide vaccine identified kras-specific epitopes tumor-specific mutant forms kras-specific multipeptide vaccine kras-peptide-based vaccine kras-driven lung tumors pe anti-cd25 antibodies kras-specific antigenic peptides assessing ifn-γ production cpg/r858/fgk adjuvant demonstrates anti-tumor efficacy tumor-specific antigenic peptides endogenous anti-tumor response antigen stimuli pma/ionomycin pmc beta search tumor-specific cd8+ cytotoxic striking anti-tumor efficacy /peptide/mhc interactions [8 apc efluro780 anti-cd3 anti-tumor cd8+ cytotoxic mediate cell-cell interactions immune suppressive environment increased cytokine-producing cd8+ amplex ultra red cancer prevention-current status cells secreting ifn-γ induced dose-dependent increases assessed anti-cancer efficacy primarily utilized vaccines tumor-infiltrating leukocytes isolated avasimibe-mediated inhibition due cytokine/chemokine analysis

Questions {❓}

• Drugging the undruggable RAS: mission possible?

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