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Title[redir]:
Transcriptome Analysis Reveals Non-Foamy Rather than Foamy Plaque Macrophages Are Pro-Inflammatory in Atherosclerotic Murine Models - PMC
Description:
Monocyte infiltration into the subintimal space and their intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of ...
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Keywords {🔍}
møs, cells, figure, foamy, atherosclerotic, foam, atherosclerosis, online, nonfoamy, genes, doi, pubmed, google, scholar, macrophages, expression, cell, aortic, pmc, lipid, article, intimal, analysis, aorta, mice, data, free, cluster, lesions, expressed, flow, inflammatory, weeks, cholesterol, showed, red, scrnaseq, cdc, found, gene, clusters, levels, formation, mouse, ldlr, increased, immune, apoe, sschibodipyhi, total,
Topics {✒️}
supplemental material_1 nihms1505499-supplement-supplemental_material_1 supplemental material_2 nihms1505499-supplement-supplemental_material_2 anti-il-1β antibody canakinumab39 single-cell rna-seq reveals hydroxypropyl-beta-cyclodextrin-mediated efflux single-cell rna-sequencing analysis supplementary materials included il-1β mrna-positive cells single-cell rna sequencing single-cell rna-sequencing hmg-coa reductase inhibitors pmc beta search detecting lipid-laden cells lipid-laden foam cells aortic single-cell suspensions il-1β mrna expression multi-parametric flow cytometry modified low-density lipoprotein atp-binding cassette transporters antigen-presenting dendritic cells bulk rna-seq analyses stained single-cell suspensions control phosphate-buffered saline apoe-aav group compared bulk rna-seq dataset cytokine/chemokine pathways similar rna-seq analysis revealed lipid-laden foamy macrophages bulk rna-seq analysis partially l-selectin dependent assessed side-scattered light online supplemental material single-cell qpcr analysis pdca1+b220intly6c+cd11b−cd64− scrna-seq analysis owing additional scrna-seq analysis d374y-hpcsk9 transgenic mice cd11b+cd64+sschibodipyhi foamy møs smooth muscle cells bodipy493/503-based lipid staining foam cell-rich area bone marrow-derived mø nihms1505499-supplement-data_set_i cytokine-cytokine receptor interaction peroxisome proliferator-activated receptor proliferating lesion-resident cells lipid-loaded plaque macrophages suggesting interferon-responsive møs lipid-rich atherosclerotic lesions cd11b−cd64−mhcii+b220+
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