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Title[redir]:
Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both? - PMC
Description:
Throughout our lives we are immersed in, and colonized by, immense and complex microbial communities. These microbiota serve as activators and early sparring partners for the progressive construction of the layers within our immune defenses and are ...
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Keywords {🔍}
gut, lupus, patients, disease, gnavus, doi, pmc, microbiome, pubmed, google, scholar, immune, microbiota, responses, article, inflammatory, intestinal, expansions, dysbiosis, autoimmune, human, free, bacteria, activity, systemic, commensal, pathogenesis, communities, studies, mice, microbial, reported, sle, influences, cell, nlm, contribute, clinical, sfb, barrier, antibody, shifts, levels, ruminococcus, erythematosus, strains, directly, bacterial, result, active,
Topics {✒️}
emerging b-cell repertoire t-cell cross-reactivity il-17 producing t-cells human rna-binding protein large cross-sectional cohort pmc beta search larger cross-sectional study α1-acid glycoprotein levels anti-ro/ssa pregnancy anti-ssb/la failed high-hurdle clinical responses low-level serum anti patients lacking anti-dsdna gut-driven systemic inflammation curr opin immunol b-cell clones primary ig repertoire rna-binding protein 16s rrna libraries serum igg anti anti-nuclear autoantibody primary sclerosing cholangitis t-cell responses serum igg responses license information pmcid tlr4 stimulatory capacity anti-ssa/ro t-cell epitopes publisher site pdf times influence dysregulation regulatory t-cells fundamental influence required obligate anaerobic species impaired intestinal barriers gnavus antibody levels cells cross-react human ro ribonucleoproteins indigestible plant polysaccharides elevated fecal levels anti-phospholipid syndrome [5] cell wall lipoglycan molecular pathways responsible subsequent immune responses higher disease activity systemic immune system host innate protein united states government final edited form phylogenetically distinct taxa greatest single class
Questions {❓}
- And what better agents than commensal microbes to serve as sparring partners for the developing immune system?
- Could the influences of gut dysbiosis on Lupus immunopathogenesis be bidirectional?
- Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both?
- We therefore wonder if the above-described Lupus disease-associated dysbiotic shifts are stable in an individual patient over time?
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