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doi, response, data, patients, fees, personal, responders, progressors, tumor, google, scholar, pubmed, fig, pmc, article, icb, tumors, free, immune, cohort, mhcii, versus, melanoma, subgroup, model, expression, ipilimumabnaive, features, antipd, test, mww, signatures, number, predictive, cancer, gene, mutations, genes, ipilimumabtreated, clinical, ipilimumab, hla, cell, higher, supplementary, resistance, extended, twosided, mutational, analysis,

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competing interests tumor-cell-specific mhc-ii expression author contributions mhc-ii-related gene expression sided mann-whitney-wilcoxon tests main content online content pmc beta search dana-farber cancer institute mann–whitney u-test tumor-draining lymph nodes pd-1/pd-l1 checkpoint therapy heterozygous single-nucleotide polymorphisms immune-related gene-sets yield gene-level expression low mhc-ii expression mhc-ii hla score solution hybrid selection anti-pd-1/pd-l1 therapy anti-ctla4 icb affected anti-ctla4 icb induces mhc-ii antigen presentation data availability statement advanced renal-cell carcinoma anti-pd1 icb monotherapy ifn-γ pathway genes org/cancer/cga/mutect high mhc-ii expression immune-activity related group single-cell-derived signatures forward-selection-based process microsatellite-stable solid tumors gene-level mutation calls [google scholar] 46 mhc-ii hla expression ffpe-based dna extraction mhc-ii transcriptomic expression bulk rna-seq data average tenfold cross-validation rna-seq quality control ipi-naïve model score ipilimumab-naive subgroup separately sample-specific sequencing depth org/cancer/cga/firehose mhc-i-related subclusters main text mhc-i-related hla data availability statements peer review information specific immune-related genes

Questions {❓}

• 12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy?

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