
NCBI . NLM . NIH . GOV {
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Title[redir]:
LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity - PMC
Description:
Dendritic cells (DCs) play a pivotal role in priming adaptive immunity. However, the involvement of DCs in controlling excessive and deleterious T cell responses remains poorly defined. Moreover, the metabolic dependence and regulation of DC ...
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Keywords {🔍}
dcs, mice, cells, doi, fig, lkbδdc, lkb, cell, pubmed, google, scholar, tregs, information, supplementary, pmc, expression, article, treg, free, tumor, signaling, analysis, increased, lkbdeficient, dendritic, splenic, homeostasis, mtor, immunity, flow, immune, metabolic, growth, thymic, cytometry, data, deficiency, metabolism, spleen, days, control, proliferation, function, regulatory, differentiation, compared, naïve, immunol, results, statistics,
Topics {✒️}
cd11c+mhc-ii+tcrβ–cd19–cd49b–cd103+ encoding 3β-hydroxysterol δ24-reductase cd11c+mhc-ii+tcrβ–cd19–cd49b cd4+cd8–cd25–yfp-foxp3– thymocytes lkb1-deficient dcs partially rectifies specific pathogen-free facility anti-il-2 + anti-cd25 blocking antibodies cd4+cd8−cd25−foxp3− thymocytes ot-ii tcr-transgenic mice cd4+yfp-foxp3+ thymocytes encoding atp-binding cassette pmc beta search caspace fitc-vad-fmk cd11c-cre-mediated gene deletion carbonyl cyanide p-trifluoromethoxyphenylhydrazone real-time pcr analysis length × width × width × π/6 af647-conjugated mhc-ii partially mtor-dependent manner restrict dc-mediated effector dendritic cell maturity/costimulation 5′amp-activated protein kinase af488-conjugated anti-cd11c modestly higher ifn-γ canonical nf-kappab activation pe-conjugated anti-foxp3 lkb1-deficient dcs exhibited 4a-diaza-s-indacene phosflow lyse/fix buffer shaping il-6−stat3 signaling naïve ot-ii cd4+ 1 μg/ml anti-cd3 05 μg/ml anti-cd3 mucosa-generated induced foxp3+ il-6-stat3 signaling pathway phospho-flow analyses verified tmt-based protein quantification lkb1-mtor signaling axis composite target/decoy database extensive liquid chromatography lkb1-deficient dcs failed mc38-egfr tumor model dc-mediated immune homeostasis antigen-processing dendritic cells kinases tbk1-ikkvarepsilon supports protective anti-tumor immunity tailed mann-whitney test tailed mann–whitney test tumor-draining lymph nodes 10 μg/ml anti-cd25
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