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Title[redir]:
Venetoclax: evidence to date and clinical potential - PMC
Description:
The emergence of targeted therapy for patients with hematological diseases has permanently altered the therapeutic landscape. Immunochemotherapy regimes are now more and more being replaced by targeted therapies due to superior efficacy and better ...
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Keywords {๐}
venetoclax, patients, doi, treatment, google, scholar, cll, pubmed, bcl, blood, phase, dose, leukemia, combination, study, aml, mrd, pmc, clinical, lymphoma, article, days, chronic, monotherapy, results, months, free, lymphocytic, nct, studies, response, cell, therapy, trials, hematological, bcell, relapsedrefractory, acute, ibrutinib, toxicity, day, median, undetectable, table, tls, trial, achieved, status, efficacy, drug,
Topics {โ๏ธ}
org/int/cancer-facts-figures/worldwide-data mechanism-based pharmacokinetic/pharmacodynamics meta-analysis eu/en/medicines/human/epar/venclyxto double-hit b-cell lymphomas narrow-spectrum p-gp substrate gov/drugs/informationondrugs/approveddrugs/ucm626499 diffuse large-cell lymphoma fixed-duration venetoclaxโrituximab led granulocyte-colony stimulating factor 1309/491w-l1tn-ufqx-t61b glucose-6-phosphate-dehydrogenase [g6pd] pediatric b-cell precursor chronic b-cell leukemias chemotherapy-free combination regimen indolent b-cell lymphomas pmc beta search tumour-derived myc mutants 58 double-hit dlbcl anti-cd20 monoclonal antibody /wp-content/uploads/2019/09/dic philadelphia chromosome-positive r-chop/g-chop r-chop versus venetoclax low-level mrd status undetectable mrd-negative status b-cell lymphoma-2 b-cell recovery relapsed/refractory multiple myeloma clonal mature b-lymphocytes poor-risk cytogenetics represented b-cell malignancies higher bcl-2/mcl-1 ratio gov/ct2/show/nct03462719 b-cell lymphomas publisher site pdf mantle cell lymphoma absolute lymphocyte count mature neoplastic large chronic lymphocytic leukemia progression-free survival high-risk 17p deletion antiapoptotic protein bcl-xl marginal zone lymphoma small lymphocytic lymphoma phase ii trial medical journal editors r-chop achieved orr cell death differ p-gp inhibitors acute myeloid leukemia
Questions {โ}
- Treatment of chronic lymphocytic leukemia with del(17p)/TP53 mutation: Allogeneic hematopoietic stem cell transplantation or BCR-signaling inhibitors?
- Gov/ct2/show/NCT03462719?
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