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Title[redir]:
YIPF2 is a novel Rab-GDF that enhances HCC malignant phenotypes by facilitating CD147 endocytic recycle - PMC
Description:
An increased surface level of CIE (clathrin-independent endocytosis) proteins is a new feature of malignant neoplasms. CD147 is a CIE glycoprotein highly up-regulated in hepatocellular carcinoma (HCC). The ability to sort out the early endosome and ...
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Keywords {🔍}
cells, doi, yipf, cell, fig, pubmed, google, scholar, hcc, rab, yipfkd, pmc, ergolgi, article, trafficking, recycling, free, hepg, protein, docx, raba, golgi, supplementary, results, expression, biol, moesmesmdocx, activation, shown, proteins, endocytosis, mmp, overexpression, transport, showed, membrane, knockdown, data, surface, pathway, cancer, complex, analysis, invasion, secretion, library, endocytic, mappit, confocal, gene,
Topics {✒️}
epor/lr-f3/cd147ep-expressed hek293-16 cells epor/lr-f3/cd147ep-expressed cells anti-mouse ab-alexa fluor594 dissipated er-/gogli-localized cd147 cytokine-receptor-based interaction trap anti-rabbit/mouse ab-fluorescence er-/gogli-localized rab5/22a dissipated er-golgi-localized cd147 rab5/rab22a/pecfp-c1 plasmids surface-bound h18ab-af488 complex homo-dimeric epor fused shorter disease-free survival pmc beta search surface-resident biontin-cd147 cd147-mediated intercellular interaction5–8 yipf2-kd markedly increased yipf2-kd significantly attenuated tat/pdna nano-complexes retroviral msp-cdna library o-linked glycan chains prolonged surface half-life crispr/cas9 lentivirus system yipf2-kd dissipated er n-linked glycosylated protein ligand-induced receptor activation er-golgi network depend fluorescence-labeled 2nd ab msp-cdna library plasmids jak-stat signaling inhibitors anti-mouse ab-af488 anti-rabbit ab-af594 p53-dependent signaling pathway maintaining er-golgi morphology integrated er/golgi morphology recognized rab5/22a/pecfp cis-golgi-localized yipfs viewed endosome-localized yipf2 microtubule-dependent endosomal sorting er-golgi biosynthetic network chimeric receptor-expressed cells anti-kdel/tgn38/gm130 abs trans-golgi-localized yipf2 n-glycosylation modifications occur chimera receptor consisting n-linked glycosylated cd147 yipf2-kd markedly enhanced er-golgi trafficing/secretion er-golgi trafficking route trans-golgi-localized cd147 separated interactor-effector design
Questions {❓}
- Some researchers may argue that Golgi is the apparatus wherein O-linked glycan chains are synthesized, how could the N-linked glycosylated CD147 be affected by YIPF2-induced Golgi morphology change?
- What is the role played by YIPF2 on CD147 transport?
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