
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors - PMC
Description:
Patients with non-small-cell lung cancer (NSCLC) whose tumours harbour activating mutations within the epidermal growth factor receptor (EGFR) frequently derive significant clinical and radiographic benefits from treatment with EGFR tyrosine kinase ...
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Keywords {๐}
egfr, cancer, lung, doi, google, scholar, pubmed, resistance, patients, pmc, article, free, mutations, erlotinib, growth, gefitinib, acquired, treatment, oncol, factor, tki, kinase, receptor, progression, tkis, clinical, epidermal, nonsmallcell, egfrmutant, mechanisms, mutation, disease, inhibitors, therapy, tyrosine, phase, cns, trial, clin, versus, plasma, cell, advanced, afatinib, amplification, nsclc, drug, inhibitor, study, nonsmall,
Topics {โ๏ธ}
t790m plasma-negative/tumour-negative results irreversible pan-erbb inhibitor plasma cell-free dna wild-type egf receptor nonsmallโcell lung cancer small-cell lung cancers t790m plasma-negative/tumour-positive small-cell lung cancer small-cell lung cancer small-cell lung cancer bbb-penetrating egfr inhibitor anti-vegf therapy delayed hepatocyte growth factor pmc beta search egfr-mutant lung cancers her2-positive breast cancers egfr-mutant lung cancer cell-free dna egfr-mutated lung cancer mutant-selective egfr tki resistant egfr-mutated adenocarcinomas tyrosine kinase inhibitor egfr-mutant lung adenocarcinoma mutant egf receptor ras-raf-mek-erk1/2 line platinum-based chemotherapy phase ib/ii trials mutant-selective egfr tkis typical bevacizumab-related toxicities single-arm trials conducted tyrosine kinase inhibitors overcomes t790m-mediated resistance advanced egfr mutation-positive egfr mutation-positive advanced tumour cell growth tyrosine kinase domain key downstream effectors key message erlotinib-related adverse events identifying t790m-mediated versus gefitinib-sensitizing egfr mutations continuous egfr-tki administration prolonged disease control small-cell carcinomas t790m lowers km[atp] single-agent egfr tki egfr-mutant nsclc continue primary end point activating egfr mutations egfr-mutant nsclc patients
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- Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pHโdependent solubility the Achilles heel of targeted therapy?
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- How much does https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res&title=Novel%20D761Y%20and%20common%20secondary%20T790M%20mutations%20in%20epidermal%20growth%20factor%20receptor%E2%80%93mutant%20lung%20adenocarcinomas%20with%20acquired%20resistance%20to%20kinase%20inhibitors&author=MN%20Balak&author=Y%20Gong&author=GJ%20Riely&volume=12&issue=21&publication_year=2006&pages=6494-6501&pmid=17085664&doi=10.1158/1078-0432.CCR-06-1570& generate monthly?
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- How much profit does https://doi.org/10.1371/journal.pmed.0040315 make?
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- https://doi.org/10.1056/NEJMp058197 income
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- https://scholar.google.com/scholar_lookup?journal=Histopathology&title=Assessment%20of%20a%20HER2%20scoring%20system%20for%20gastric%20cancer:%20results%20from%20a%20validation%20study&author=M%20Hofmann&author=O%20Stoss&author=D%20Shi&volume=52&issue=7&publication_year=2008&pages=797-805&pmid=18422971&doi=10.1111/j.1365-2559.2008.03028.x&'s total income per month
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