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Title[redir]:
SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis - PMC
Description:
The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the role of SOX12 and the mechanism by which it is dysregulated in colorectal cancer (CRC) remain unclear. Here we analyzed ...
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Keywords {🔍}
sox, crc, cells, doi, cell, expression, cancer, metastasis, asns, gls, fig, supplementary, pubmed, google, scholar, asparagine, tissues, tumor, pmc, patients, mice, proliferation, article, free, lung, table, hifα, promoter, human, levels, significantly, overexpression, metabolism, analysis, amino, acid, lasparaginase, increased, luciferase, data, synthesis, progression, growth, group, compared, panel, usa, recurrence, groups, staining,
Topics {✒️}
hif-1α/sox12/gls/got2/asns pathway contributes fourth hif-1α-binding site δδct = δctexpressing vector – δctcontrol vector putative hif-1α-binding sites sequence-specific dna-binding protein dna-binding hmg-box domain4 gls/got2/asns-mediated asparagine synthesis potential hif-1α-binding sites sox12-mediated asparagine dysregulation sox12-binding site disrupted potential cis-regulatory elements anti-β-actin antibody pmc beta search sox12 knockdown-induced suppression sox12-mediated asparagine synthesis hypoxia-inducible factor 1α sds-polyacrylamide gel electrophoresis performed site-directed mutagenesis sex-determining region y sox12-mediated crc progression mutant kras-driven cancers hif-1α-binding sites disease-free survival time 100 mg/kg d-luciferin e-stained lung tissues kaplan–meier analysis revealed hif-1α silencing exerted u-13c5-labeled metabolites l-asparaginase group compared kaplan–meier analysis showing fresh-frozen crc tissues hif-1α transactivated sox12 rt-pcr analysis showing amino acid metabolism site-directed mutagenesis serum-free medium license information pmcid l-asparaginase represents cell signaling technology tumor-bearing mice underwent sox12-overexpressing crc cells slc25a22 promotes proliferation genome-wide promoter analysis amino acid disturbances mantle cell lymphoma sox12-binding site sox12-induced gls transactivation sry-related gene expressed sox12 silencing suppresses crc cell proliferation
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Analytics and Tracking {📊}
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