
NCBI . NLM . NIH . GOV {
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Title[redir]:
Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma - PMC
Description:
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, which is mainly due to late diagnosis and profound resistance to treatment. The latter is to a large extent attributed to the tumor stroma that is exceedingly prominent in PDAC and ...
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Keywords {🔍}
tissue, slices, cancer, culture, cells, doi, cell, pancreatic, tumor, pubmed, slice, outgrowth, fig, google, scholar, activity, time, stroma, medium, pmc, nonneoplastic, surface, pdac, study, conditions, cultured, vivo, article, cellular, data, supplementary, staining, differentiation, drug, viability, metabolic, free, system, human, differentiated, cancerous, points, pancreas, testing, epithelial, proliferation, analysis, oxygen, grade, normoxic,
Topics {✒️}
1x pen-strep solution kras-driven lung tumours sparse cd3-positive t-cells pmc beta search genetically-engineered mouse models α-smooth muscle actin author contributions ductal-type epithelial cells ice-cold transport medium license information pmcid donor-paired tissue slices donor-matched tissue slices precision-cut slice cultures precision-cut tissue slices precision-cut organ slices precision-cut tumor slices precision-cut tissue culture pancreatic ductal adenocarcinoma data availability statements cd3-positive t-cells surgical resection specimens precision-cut pdac slices footnotes publisher stroma-specific treatment strategies smooth muscle actin discussion preclinical require precise quantification pancreatic stellate cells12 ductal-epithelial origin ice-cold hank balanced salt solution culture ids ot1-ot12 ductal epithelial cells transmission electron microscopy publisher site pdf digital slide viewer schematic diagram showing supplementary materials included neoplastic ductal epithelium smooth muscle cells cd34-positive stromal cells pancreatic parenchyma results invasive ductal carcinoma poorly differentiated pdacs paired slices obtained differentiated tumors formed biopsy material e-stained section strong pimonidazole staining drug sensitivity screening
Questions {❓}
- Morphological heterogeneity in ductal adenocarcinoma of the pancreas - Does it matter?
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