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cells, sfb, figure, mice, cll, cell, expression, bcr, atm, signaling, doi, mutation, dmcll, pubmed, google, scholar, table, pmc, analysis, mouse, shown, human, genes, article, data, free, deletion, leukemia, senescence, sfbke, clls, mutations, blood, cellular, samples, ibrutinib, cancer, events, lines, observed, lymphocytic, dna, gene, performed, chronic, versus, staining, splicing, splenic, nature,

Topics {✒️}

dleu2/mir-15a/16–1 cluster controls antigen-independent cell-autonomous signalling generate sf3b1fl/+atmfl/fl mice obtain cd19-cre+/−sf3b1fl/+atmfl/+ cold phosphate-buffered saline celltiter-glo® luminescent assay supplementary materials included pmc beta search immune-based selective pressure star methods contact multiple lineage-specific markers duhren-von minden crossed sf3b1fl/+atmfl/fl dna double-strand breaks rna-seq analysis revealed nci 1r01 ca155010-01a1 cd19-cre+/−sf3b1fl/+atmfl/+ positive/negative ion-switching indolent b-cell lymphoma b-chronic lymphocytic leukemia dm-cll versus dm rna-seq data reported 20 μg/ml α-igm large-scale genetic characterizations cd19-cre+/−sf3b1+/+atmfl/+ monoclonal b-cell lymphocytosis rna-seq data confirmed dana-farber cancer institute circulating b220+cd5+ cells mapk/erk signaling pathway sf3b1-k700e mutation present heterozygous sf3b1-k700e mutation heterozygous sf3b1-k700e allele overcoming oncogene-induced senescence dm-cll cells showed target-decoy strategy combined homozygous cd19-cre mice lymphoma research foundation distinct bcr-signaling pathways sf3b1-k700e floxed mice activated sf3b1-k700e allele immunohistochemistry analysis demonstrated te raa lymphoma society fellowship tandem mass tag data availability statements differentially expressed genes/proteins α-p-akt s473 performed rna-seq analysis bcr signaling transduction

Questions {❓}

• Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3?

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