
NCBI . NLM . NIH . GOV {
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Title[redir]:
Checkpoint blockade immunotherapy induces dynamic changes in PD-1−CD8+ tumor-infiltrating T cells - PMC
Description:
An improved understanding of the anti-tumor CD8+ T cell response after checkpoint blockade would enable more informed and effective therapeutic strategies. Here we examined the dynamics of the effector response of CD8+ tumor-infiltrating lymphocytes ...
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Keywords {🔍}
cells, tils, figure, cell, blockade, timpd, google, scholar, doi, pubmed, effector, mice, pmc, expression, pdcd, article, checkpoint, genes, free, data, subsets, signature, subset, expressed, response, cancer, tumor, gene, tcf, memoryprecursorlike, mcova, treated, memory, signatures, test, effectorlike, isotype, cdlslamfhicxcr, differentially, cxcr, til, group, eicretcfflfl, immunity, transcriptional, naïve, memoryprecursor, therapy, antibodies, analysis,
Topics {✒️}
droplet-based single-cell rna-seq full-length rna-seq libraries e8i-cre+ tcf7fl/fl mice e8i-cre+tcf7fl/fl mice pgc-1alpha-responsive genes involved anti-ctla-4+anti-pd-1−treated cancer patients mc38-ova tumor-bearing mice isotype-treated mc38ova-bearing mice e8i-cre−tcf7fl/fl e8i-cre+tcf7fl/fl e8i-cre-tcf7fl/fl single-cell rna-seq ova-specific pd1−cd8+ tils tim-3+pd-1 blockade-treated mice t-bet transcription factor tumor antigen-specific memory-precursor [google scholar] maekawa mc38-ova bearing mice single-cell rna profiles pre-ranked list mode h-2kb-ova257–264 dextramers annotate chip-seq peaks cd62l−slamf7hicx3cr1+pd-1−cd8+ tils pmc beta search de mingo pulido cd8+ tumor-infiltrating lymphocytes anti-tim-3+anti-pd-1 treatment long-lasting gene induction tim-3+pd-1 blockade-treated cells establish long-lasting immunity tumor-antigen specific precursors tumor-antigen-specific precursors crossing tcf7flox/flox mice tumor antigen-specific cd8+ ova-specific cd8+ tils activation-induced cell death gene-set enrichment analysis directs lineage-specific expression sustain long-term responses sustain long-lasting immunity pd-1−cd8+ tumor-infiltrating cd62l−slamf7hicx3cr1−pd-1−cd8+ subset cd62l−slamf7hicx3cr1+pd-1−cd8+ subset tumor-expressed ova antigen prolonged interleukin-2ralpha expression tcf7 chip-seq data pd-1−cd8+ til populations tim-3+pd-1 blockade shifted tim-3+pd-1 blockade elicited data-driven phenotypic dissection
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- Income figures for https://github.com/ncbi
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