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Keywords {🔍}

cells, stem, cell, immune, doi, pubmed, google, scholar, tissue, pmc, article, free, inflammatory, macrophages, tregs, hair, niche, tissues, regeneration, resident, repair, inflammation, signals, nature, figure, innate, muscle, response, intestinal, hscs, immunity, memory, progenitors, epithelial, promote, skin, homeostasis, regenerative, differentiation, function, role, iscs, injury, activation, wound, responses, damage, stress, follicle, hematopoietic,

Topics {✒️}

immune-stem cell cross-talk circular rna cis-gas circular rna “cis-gas” tuft-cell-derived il-25 regulates pro-inflammatory cytokine il-1β pmc beta search β-glucan-dependent hsc training aim2-deficient mice display helper t-cell identity immune-stem cell interactions shorter-lived progenitors charged multiple receptor-ligand interactions inflammation-experienced stem cells wnt/β-catenin pathways stem cell-immune crosstalk immune-stem cell crosstalk stem cell-derived ccl2 intestinal stem-cell niche eosinophil-derived instructive cues shorter-lived proliferative progenitors secreted pro-inflammatory factors immune-mediated tissue damage �western” diet metabolite genetically nonidentical allo-hscs genome-wide association study haematopoietic stem-cell niche paneth cell-derived signals tissue-specific stem cells basal progenitor programs extra-lymphoid tissues seed tissues early damage-sensing stem cells innate lymphoid cell low-grade systemic inflammation respiratory epithelial progenitors multiple progenitor populations play context-specific roles interleukin-33-dependent accumulation age-related defects result age-driven inflammatory circuit mesenchymal stem cells intestinal stem cell notch ligand delta casanova-acebes feed-forward circuit stem cell signaling inflammation-inducing noxious agents bmp inhibitor levels inflammasome activator nlrp3 age-related tissue dysfunction

Questions {❓}

• Are macrophages and Tregs obligatory residents of all stem cell niches?
• Do stem cells in these tissues more readily take their cues from immune cells under physiological conditions, while other less immunologically active tissues call upon their immune partners only under duress?
• Is this process initiated by stem cells themselves, or do other members of the niche control immune localization in their ecosystem?

Social Networks {👍}(6)

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• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

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• https://doi.org/10.1038/nature04444 income
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• Income figures for https://doi.org/10.1126/science.aan4153
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• How much revenue does https://scholar.google.com/scholar_lookup?journal=Annual%20Review%20of%20Immunology&title=Regulatory%20T%20cells:%20mechanisms%20of%20differentiation%20and%20function&author=SZ%20Josefowicz&author=L-F%20Lu&author=AY%20Rudensky&volume=30&publication_year=2012&pages=531-564&pmid=22224781&doi=10.1146/annurev.immunol.25.022106.141623& bring in?
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• How much profit is https://scholar.google.com/scholar_lookup?journal=Cell&title=BCG%20Educates%20Hematopoietic%20Stem%20Cells%20to%20Generate%20Protective%20Innate%20Immunity%20against%20Tuberculosis&author=E%20Kaufmann&author=J%20Sanz&author=JL%20Dunn&author=N%20Khan&author=LE%20Mendon%C3%A7a&volume=172&publication_year=2018&pages=176-190&pmid=29328912&doi=10.1016/j.cell.2017.12.031& making per month?
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• How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=Impaired%20Epidermal%20to%20Dendritic%20T%20Cell%20Signaling%20Slows%20Wound%20Repair%20in%20Aged%20Skin&author=BE%20Keyes&author=S%20Liu&author=A%20Asare&author=S%20Naik&author=J%20Levorse&volume=167&publication_year=2016&pages=1323-1338&pmid=27863246&doi=10.1016/j.cell.2016.10.052& generate monthly?
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• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Cell&title=Tissue-Resident%20Macrophage%20Enhancer%20Landscapes%20Are%20Shaped%20by%20the%20Local%20Microenvironment&author=Y%20Lavin&author=D%20Winter&author=R%20Blecher-Gonen&author=E%20David&author=H%20Keren-Shaul&volume=159&publication_year=2014&pages=1312-1326&pmid=25480296&doi=10.1016/j.cell.2014.11.018&?
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• What's the income generated by https://doi.org/10.1016/j.cell.2015.06.001 each month?
• How much income is https://scholar.google.com/scholar_lookup?journal=Cell&title=Critical%20Role%20for%20the%20DNA%20Sensor%20AIM2%20in%20Stem%20Cell%20Proliferation%20and%20Cancer&author=SM%20Man&author=Q%20Zhu&author=L%20Zhu&author=Z%20Liu&author=R%20Karki&volume=162&publication_year=2015&pages=45-58&pmid=26095253&doi=10.1016/j.cell.2015.06.001& earning monthly?
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• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Cell&title=Immunosurveillance%20by%20hematopoietic%20progenitor%20cells%20trafficking%20through%20blood,%20lymph,%20and%20peripheral%20tissues&author=S%20Massberg&author=P%20Schaerli&author=I%20Knezevic-Maramica&author=M%20K%C3%B6llnberger&author=N%20Tubo&volume=131&publication_year=2007&pages=994-1008&pmid=18045540&doi=10.1016/j.cell.2007.09.047&?
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• How much does https://scholar.google.com/scholar_lookup?journal=Science%20(New%20York,%20N.Y.)&title=Trained%20immunity:%20A%20program%20of%20innate%20immune%20memory%20in%20health%20and%20disease&author=MG%20Netea&author=LAB%20Joosten&author=E%20Latz&author=KHG%20Mills&author=G%20Natoli&volume=352&publication_year=2016&pages=aaf1098-aaf1098&pmid=27102489&doi=10.1126/science.aaf1098& rake in every month?
• Check the income stats for https://doi.org/10.4049/jimmunol.1502139
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• https://doi.org/10.1038/nm.3651's financial summary
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• How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Allergic%20inflammatory%20memory%20in%20human%20respiratory%20epithelial%20progenitor%20cells&author=J%20Ordovas-Montanes&author=DF%20Dwyer&author=SK%20Nyquist&author=KM%20Buchheit&author=M%20Vukovic&publication_year=2018a&pmid=30135581&doi=10.1038/s41586-018-0449-8& pull in?
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Nature&title=Allergic%20inflammatory%20memory%20in%20human%20respiratory%20epithelial%20progenitor%20cells&author=J%20Ordovas-Montanes&author=DF%20Dwyer&author=SK%20Nyquist&author=KM%20Buchheit&author=M%20Vukovic&volume=139&publication_year=2018b&pages=1752&pmid=30135581&doi=10.1038/s41586-018-0449-8&?
• How much money does https://doi.org/10.1016/j.bbr.2008.12.016 make?
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• What's the financial gain of https://doi.org/10.1038/nature09114?
• What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Nature&title=Genome-wide%20association%20study%20in%20alopecia%20areata%20implicates%20both%20innate%20and%20adaptive%20immunity&author=L%20Petukhova&author=M%20Duvic&author=M%20Hordinsky&author=D%20Norris&author=V%20Price&volume=466&publication_year=2010&pages=113-117&pmid=20596022&doi=10.1038/nature09114&?
• How much does https://doi.org/10.1038/nature06457 bring in each month?
• What's the profit of https://scholar.google.com/scholar_lookup?journal=Nature&title=Cyclic%20dermal%20BMP%20signalling%20regulates%20stem%20cell%20activation%20during%20hair%20regeneration&author=MV%20Plikus&author=JA%20Mayer&author=D%20la%20Cruz,%20de&author=RE%20Baker&author=PK%20Maini&volume=451&publication_year=2008&pages=340-344&pmid=18202659&doi=10.1038/nature06457&?
• What's the income of https://doi.org/10.1136/gut.2006.090456?
• https://scholar.google.com/scholar_lookup?journal=Gut&title=Wound%20healing%20and%20fibrosis%20in%20intestinal%20disease&author=F%20Rieder&author=J%20Brenmoehl&author=S%20Leeb&author=J%20Sch%C3%B6lmerich&author=G%20Rogler&volume=56&publication_year=2007&pages=130-139&pmid=17172588&doi=10.1136/gut.2006.090456&'s revenue stream
• What's the profit of https://doi.org/10.1038/nri3464?
• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Nature%20Reviews.%20Immunology&title=The%20plasticity%20and%20stability%20of%20regulatory%20T%20cells&author=S%20Sakaguchi&author=DAA%20Vignali&author=AY%20Rudensky&author=RE%20Niec&author=H%20Waldmann&volume=13&publication_year=2013&pages=461-467&pmid=23681097&doi=10.1038/nri3464&?
• Learn how profitable https://doi.org/10.1038/s41467-018-03638-6 is on a monthly basis
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• What's the financial intake of https://doi.org/10.1016/B978-0-12-416022-4.00003-2?
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• What's https://doi.org/10.1016/j.chom.2017.03.002's gross income?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Cell%20Host%20&%20Microbe&title=Age-Associated%20Microbial%20Dysbiosis%20Promotes%20Intestinal%20Permeability,%20Systemic%20Inflammation,%20and%20Macrophage%20Dysfunction&author=N%20Thevaranjan&author=A%20Puchta&author=C%20Schulz&author=A%20Naidoo&author=JC%20Szamosi&volume=21&publication_year=2017&pages=455-466&pmid=28407483&doi=10.1016/j.chom.2017.03.002& generate?
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• What's https://scholar.google.com/scholar_lookup?journal=Nature%20Medicine&title=Inflammasome-independent%20role%20of%20AIM2%20in%20suppressing%20colon%20tumorigenesis%20via%20DNA-PK%20and%20Akt&author=JE%20Wilson&author=AS%20Petrucelli&author=L%20Chen&author=AA%20Koblansky&author=AD%20Truax&volume=21&publication_year=2015&pages=906-913&pmid=26107252&doi=10.1038/nm.3908&'s gross income?
• How profitable is https://doi.org/10.1126/science.1064081?
• Income figures for https://scholar.google.com/scholar_lookup?journal=Science%20(New%20York,%20N.Y.)&title=Physiological%20migration%20of%20hematopoietic%20stem%20and%20progenitor%20cells&author=DE%20Wright&author=AJ%20Wagers&author=AP%20Gulati&author=FL%20Johnson&author=IL%20Weissman&volume=294&publication_year=2001&pages=1933-1936&pmid=11729320&doi=10.1126/science.1064081&
• How much revenue does https://doi.org/10.1016/j.cell.2017.11.018 generate?
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• Revenue of https://doi.org/10.1016/j.cell.2017.03.038
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Cell&title=Epithelial-Mesenchymal%20Micro-niches%20Govern%20Stem%20Cell%20Lineage%20Choices&author=H%20Yang&author=RC%20Adam&author=Y%20Ge&author=ZL%20Hua&author=E%20Fuchs&volume=169&publication_year=2017&pages=483-496&pmid=28413068&doi=10.1016/j.cell.2017.03.038& generate?
• https://doi.org/10.1038/srep07820's total income per month
• Earnings of https://scholar.google.com/scholar_lookup?journal=Scientific%20Reports&title=Mesenchymal%20stem%20cells%20detect%20and%20defend%20against%20gammaherpesvirus%20infection%20via%20the%20cGAS-STING%20pathway&author=K%20Yang&author=J%20Wang&author=M%20Wu&author=M%20Li&author=Y%20Wang&volume=5&publication_year=2015&pages=7820&pmid=25592282&doi=10.1038/srep07820&
• https://doi.org/10.3390/ijms17122085's total income per month
• How much profit is https://scholar.google.com/scholar_lookup?journal=International%20Journal%20of%20Molecular%20Sciences&title=Inflammation%20in%20Chronic%20Wounds&author=R%20Zhao&author=H%20Liang&author=E%20Clarke&author=C%20Jackson&author=M%20Xue&volume=17&publication_year=2016&pages=2085&pmid=27973441&doi=10.3390/ijms17122085& making per month?
• Financial intake of https://doi.org/10.1126/science.1190310
• How much does https://scholar.google.com/scholar_lookup?journal=Science%20(New%20York,%20N.Y.)&title=Immunology.%20Tumor%20immune%20evasion&author=CL%20Zindl&author=DD%20Chaplin&volume=328&publication_year=2010&pages=697-698&pmid=20448171&doi=10.1126/science.1190310& rake in every month?
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• What's https://www.nlm.nih.gov/web_policies.html's gross income?
• Find out how much https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office earns monthly
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• How much does https://www.usa.gov/ generate monthly?

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