
NCBI . NLM . NIH . GOV {
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Title[redir]:
Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells - PMC
Description:
To balance immunity and tolerance, the endogenous pool of Foxp3+ regulatory T (Treg) cells is tightly controlled, but the underlying mechanisms of this control remain poorly understood. Here we show that the number of Treg cells is negatively ...
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Keywords {🔍}
mice, dcs, treg, cells, cell, doi, lkb, cdccrelkbff, fig, lkbff, supplementary, pubmed, google, scholar, lkbdeficient, lps, oxl, regulatory, immune, proliferation, pmc, expression, article, expansion, analysis, days, treated, free, sorted, data, results, nfκb, biolegend, number, flow, activation, coli, immunol, cfselabelled, function, cytometric, gene, protein, responses, increased, foxp, signalling, tolerance, spleen, splenic,
Topics {✒️}
lkb1-controlled nf-κb signalling ampk-sirt1-pgc-1alpha pathway coli pre-treatment-induced protection inhibit nf-κb signalling nuclear/cytosol fractionation reagent author contributions contributor information nf-κb p65 binding bacteria pre-treatment-induced increase nf-kappab transcription factors ifn-γ-producing ot-ii lkb1-deficient dcs pre-treated nf-kappab-dependent transcription phosphorylated nf-κb p65 phospho-nf-κb p65 cell-cell contact involving retinoic acid-dependent mechanism fas/fas ligand-dependent mechanism bacteria/lps-induced protein depletion nf-κb/ox40l pathway nf-κb inhibitor sc75741 prostaglandin e2-dependent expansion lkb1 depletion-induced expansion pe-cy7-anti-cd278 bone-marrow-derived dendritic cells mucosa-generated induced foxp3+ pmc beta search tnfr-related molecule ox40 cd40-signalling abrogates induction pro-inflammatory cytokines il1α short-term dt treatment footnotes publisher antigen-presenting cell development pe-cy7-anti-cd8α human cd4+cd25+ regulatory cd40/cd40l costimulation blockade pro-inflammatory transcriptional programme cell type-conditioned function pe-anti-ifn-γ ikk/ikbα-independent activation antigen-presenting cell function sds-page lkb1-deficient dc function apc-cy7-anti-cd4 pe-cy7-anti-cd11c antigen-specific peripheral shaping black dots mark genes lps-induced lkb1 depletion real-time pcr analysis cfse-labelled treg cells
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