NCBI . NLM . NIH . GOV {
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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC6189459/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC6189459/. The analysis below is for the second page.
Title[redir]:
Growth Differentiation Factor 15 Maturation Requires Proteolytic Cleavage by PCSK3, -5, and -6 - PMC
Description:
Growth differentiation factor 15 (GDF15) is a secreted protein with pleotropic functions from the transforming growth factor β (TGF-β) family. GDF15 is synthesized as a precursor and undergoes proteolytic cleavage to generate mature GDF15. KEYWORDS: ...
Title[redir]:
Growth Differentiation Factor 15 Maturation Requires Proteolytic Cleavage by PCSK3, -5, and -6 - PMC
Description:
Growth differentiation factor 15 (GDF15) is a secreted protein with pleotropic functions from the transforming growth factor β (TGF-β) family. GDF15 is synthesized as a precursor and undergoes proteolytic cleavage to generate mature GDF15. KEYWORDS: ...
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Keywords {🔍}
pcsk, gdf, doi, progdf, mouse, pubmed, google, scholar, heart, mature, growth, disease, fig, protein, pmc, maturation, cleavage, cardiac, mice, cell, factor, cleave, results, control, aav, article, western, proteins, essential, family, enzymes, vivo, blot, cells, free, protease, wang, cardiomyocytes, hormone, expression, receptor, preprogdf, nlm, liu, precursor, studies, processing, inhibitors, human, performed,
Topics {✒️}
c-terminal myc-flag-tagged pre-pro-gdf15 basic residues arg/lys-x2n-arg/lys� pan-pcsk inhibitor decanoyl-rvkr-cmk promoter-driven pre-pro-gdf15 aav9-ctnt-green fluorescent protein long-acting mic-1/gdf15 molecules c-terminal mature gdf15 macrophage inhibitory cytokine cardiac errα/γ ko tgf-beta superfamily member pmc beta search cardiac errα/γ knockout lithium heparin-coated microvette sample unequal-variance student' brain-derived neurotrophic factor estrogen-related receptor alpha tgf-beta superfamily growth-differentiation factor 15 human pre-pro-gdf15 effectively processed pro-gdf15 cardiac tissue-specific expression strong appetite-suppressing effect mouse pre-pro-gdf15 effectively process pro-gdf15 errgamma-regulated mitochondrial metabolism littermate control αhet/γwt efficiently cleave pro-gdf15 pro-gdf15 band densities attractive therapeutic agent/target enzyme-linked immunosorbent assay pathogen-free environment control αhet/γwt mice regulates body growth r188q mutant gdf15-mf western blot analysis pre-pro-gdf15 quantitative reverse transcription-pcr cell-type-independent enzymes specific pcsk protein pcsk6 cleave pro-gdf15 v5h6-tagged pcsk v5h6-tagged pcsk1 decanoyl-rvkr-cmk aav-injected heart lysates postnatal body growth human cdna encoding pediatric body growth nih grant dk111495 gdf15-mf plasmid tagged pcsk vectors
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