
NCBI . NLM . NIH . GOV {
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Title[redir]:
Cardiovascular and Renal Outcomes With Canagliflozin According to Baseline Kidney Function: Data From the CANVAS Program - PMC
Description:
Supplemental Digital Content is available in the text. Keywords: canagliflozin; cardiovascular diseases; diabetes mellitus, type 2; glomerular filtration rate; kidney; renal insufficiency, chronic; sodium glucose cotransporter 2; treatment outcome
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Keywords {🔍}
egfr, doi, cardiovascular, kidney, canagliflozin, participants, renal, outcomes, diabetes, disease, data, function, effects, risk, mlmin, baseline, heterogeneity, google, scholar, pubmed, type, placebo, ckd, canvas, outcome, effect, study, program, similar, subgroups, trial, events, levels, adverse, sglt, time, research, chronic, glucose, treatment, figure, pmc, people, analysis, janssen, safety, blood, patients, inhibitors, trials,
Topics {✒️}
supplementary material cir-138-1537-s001 web-based response system empa-reg outcome randomised empa-reg outcome investigators pmc beta search computer-generated randomization schedule empa-reg outcome trial including renin-angiotensin system empa-reg outcome study fatal/nonfatal myocardial infarction end-stage kidney disease urine albumin/creatinine ratio acute dose-dependent decline nonlinear mixed-effect model urinary albumin/creatinine ratio medical research council senior research fellowship glomerular filtration rate similar mixed-effect model blood pressure–lowering agents placebo-controlled trial program blood pressure–lowering effects sas enterprise guide license information pmcid reassessing current limitations [google scholar] 14 systolic blood pressure nonfatal myocardial infarction urinary glucose excretion received unrestricted funding alter glomerular hemodynamics independently adjudicated composites preserved kidney function mixed-effect models academic research organization intensive glucose lowering likelihood ratio test received research support canagliflozin significantly slowed possibly greater benefits cox regression models highly skewed distribution alternative energy substrate manipulating tubuloglomerular feedback south wales sydney bristol-myers squibb proportional hazards model diabetic animal models friedewald wt action publisher site pdf
Questions {❓}
- Are SGLT2 inhibitors ready for prime time for CKD?
- Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study?
- What Are the Clinical Implications?
- What Is New?
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