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Title[redir]:
Autophagy-independent induction of LC3B through oxidative stress reveals its non-canonical role in anoikis of ovarian cancer cells - PMC
Description:
Cancer cells display abnormal redox metabolism. Autophagy, anoikis and reactive oxygen species (ROS) play a regulatory role during metastasis. LC3 is a well-known essential molecule for autophagy. Therefore, we wanted to explore the molecular ...
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Keywords {🔍}
cells, mahanine, doi, autophagy, lcb, fig, cell, pubmed, google, scholar, cancer, anoikis, primary, apoptosis, mahaninetreated, pmc, treated, ros, article, analyzed, role, decreased, free, enhanced, death, inhibition, molecules, patients, min, incubated, atg, reduced, antibodies, increased, autophagosomes, ovcar, oxidative, observed, antibody, autophagosome, pcast, formation, facs, showed, stained, western, blot, tumor, similarly, oxidativestress,
Topics {✒️}
impairing pi3k-akt/mtor-mediated pathway ccz1/mon1 regulator c18orf8/rmc1 ice-cold phosphate-buffered saline im-pro-ii-reverse transcription system unfolded/inactive-proteins/damaged-organelles pi3k/akt/mtor/p70s6k inhibition β-amyloid-induced neuron death mammalian serine/threonine-protein kinase bio-rad trans-uv system oxidative-stress-induced enhanced atg egfp-lc3band sirna-transfected cells integrin/fak/src-mediated regulation autophagy-inhibition increases radio-sensitivity fluorescence-tagged anti-integrin-β3 sirna/plasmid dna serving ulk1/2–atg13–fip200–atg101 complex19 green-dots confirming enhanced-autophagy egfp-lc3b plasmid dna exhibited anti-proliferative activity ros-producing pro-oxidant molecule west pico-ecl system west-pico ecl system detachment-induced cell death oxidative stress-induced apoptosis oxidative-stress inhibits proliferation high-grade serous histology mahanine-induced higher annexin jnk/c-jun pathway hrp-conjugated secondary antibodies oxidative stress-induced inhibition mahanine-induced oxidative stress mahanine-induced oxidative-stress integrin-mediated cell death23 nac-pretreated mahanine-treated cell intra-operative tumor distribution snail/slug/integrin-β3/fak protein a-sepharose 4b fluorescence-conjugated secondary antibody structure-based kinase profiling 3-dioxygenase-mediated immune suppression ros-induced enhanced-lc3b mahanine-exposed egfp-lc3b transfected atg5–atg12/atg16l1-conjugate similar dose-dependent decreased platinum/taxol-based chemotherapy mir-200c inhibits autophagy pmc beta search increasing cell–cell contacts mahanine-treated pa1/ovcar-3 exhibited atg5–atg12/atg16 complex
Questions {❓}
- ATG proteins: Are we always looking at autophagy?
- Next, we asked the question, is there any relation between enhanced LC3B and EMT-molecules by LC3B in mahanine-treated cells?
- P62, an autophagy hero or culprit?
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