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Title[redir]:
Synergistic effect of metformin on sorafenib in in vitro study using hepatocellular carcinoma cell lines - PMC
Description:
Hepatocellular carcinoma (HCC) recurrence remains a great concern following hepatic resection and liver transplantation. We investigated the metformin-induced cytotoxic effects on sorafenib in an in vitro study using HCC cell lines. This research ...
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Keywords {🔍}
metformin, sorafenib, cell, doi, study, effects, tumor, hcc, pubmed, google, scholar, synergistic, vitro, patients, cancer, hepatocellular, carcinoma, lines, antitumor, liver, advanced, fig, pmc, effect, apoptosis, survival, assays, nlm, revealed, expression, clinical, line, xenograft, cells, rtpcr, cytotoxic, patientderived, hbx, administration, mtor, pathway, protein, ampk, res, ncbi, search, kim, hepg, results, risk,
Topics {✒️}
6-diamidino-2-phenylindole-hoechst staining hepato-biliary-pancreatic surgery amp-activated protein kinase tumor necrosis factor-α rag gtpase-dependent manner pmc beta search drug-treated cells relative rapamycin-dependent translation initiation median progression-free survival metformin-induced cytotoxic effects patient-derived xenograft inhibit hbv-derived hcc population-based cohort study lc3-ii assays revealed publisher site pdf generation xenograft tumor cell-cycle arrest license information pmcid advanced hepatocellular carcinoma hcc cell lines recurrent hepatocellular carcinoma hepatocellular carcinoma cells noticeable synergistic effect vitro drug concentrations increased tumor aggressiveness anti-tumor effect dose-dependent manner experience tumor progression antitumor effects revealed line chemotherapeutic agent kras-mutant advanced statistically significant difference acknowledgements disclosure methods study design synergistic cytotoxic effect human hcc tissue chronic liver disease concentration-dependent decrease tnf-α revealed united states government randomized controlled trials polyacrylamide gel electrophoresis asia-pacific region phase iii randomised placebo-controlled trial le marchand-brustel van der burg expert opin pharmacother treating advanced hcc established cell line
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