
NCBI . NLM . NIH . GOV {
}
Title[redir]:
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers - PMC
Description:
The biological determinants of sensitivity and resistance to immune checkpoint blockers are not completely understood. To elucidate the role of intratumoral T-cells and their association with the tumor genomic landscape, we perform paired whole ...
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Keywords {๐}
doi, tumor, tcell, immune, cells, pubmed, google, scholar, mutational, pmc, lung, article, checkpoint, cancer, free, cases, load, neoantigens, blockers, mutant, cell, nsclc, mutations, patients, fig, blockade, til, association, classi, predicted, tumors, supplementary, data, treated, response, gzb, tcells, level, dna, type, survival, expression, sequencing, tils, candidate, low, samples, benefit, melanoma, levels,
Topics {โ๏ธ}
pre-treatment formalin-fixed paraffin-embedded biotynilated tyramide/streptavidine-alexa750 conjugate anti-pd-l1 antibody mpdl3280a anti-ifn-ฮณ-pacific blue neoantigen-specific t-cell reactivity mutant peptide-hla-a2 interaction sophisticated technical/bioinformatic resources elevated t-cell gzb/ki-67 low t-cell gzb/ki-67 low t-cell gzb/ki-6 nod-scid il2rgc-/- mice cd4+/t-bet+ cell phenotype user-defined tissue compartments9 t-cell cytolytic potential/proliferation b-lymphoblastoid lcl-174 cells goat anti-rabbit alexa546 anti-mouse igg1 antibody anti-mouse igg2a antibody small-cell lung cancer pd-l1 ihc tests demonstrated t-cell reactivity local ifn-ฮณ production situ t-cell activation/proliferation local t-cell infiltration pmc beta search relative pe-cy7 fluorescence altered/foreign nucleic acids patient-derived xenograft model author contributions 3-year progression-free survival cd8 t-cell responses26โ30 burrow-wheeler aligner-mem patient t-cell reactivity immuno-selected human cells kaplanโmeier graphical analysis mismatch-repair deficient carcinomas anti-cd8-apc-cy7 t-cell ki-67 signal high-throughput sequencing data k562 expressing hla-a2 highest hla-a2 signal cytotoxic t-cell trapping t-cell tumor infiltration tumor t-cell infiltration anti-cd3-percp cy5 greater anti-tumor effect anti-tnf-ฮฑ-fitc pre-existing cd3+ tils peptide/nucleic acid vaccines autologous patient t-cells38
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Analytics and Tracking {๐}
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