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Title[redir]:
A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming - PMC
Description:
Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic ...
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Keywords {🔍}
enzymes, translation, trna, melanoma, pmc, trnamodifying, doi, pubmed, google, scholar, resistance, cancer, modifications, article, elp, hifα, codons, free, nlm, study, metabolic, cells, authors, cell, ncbi, search, rna, exciting, rapino, role, decoding, braf, reprogramming, metabolism, specific, drug, information, glycolytic, show, modification, regulation, codon, proteins, demonstrate, increased, levels, elongator, leidel, targeted, inhibition,
Topics {✒️}
u34 trna‐modifying enzymes gene‐specific translation downstream codon‐dependent translation regulation enhanced codon‐dependent translation targeting rna‐modifying enzymes hypoxia‐inducible factor 1α rna‐modifying enzymes require pmc beta search elevated pi3k/mtor signaling codon‐anticodon base pairing codon‐mediated translation regulation conferring mtorc2‐dependent resistance trna‐modifying enzymes ubiquitin‐related modifier 1 publisher site pdf kras‐driven therapeutic resistance u34 trna modifications license information pmcid hif1α mrna indicating codon translation rates generate 5‐methoxycarbonylmethyl‐2‐thiouridine references agris pf ribosome profiling experiments transcript‐specific translation key enzymes required rewiring translation mediated promoting glycolytic metabolism trna anticodon loop skin cancer cells controlling trna function trna species bypass codon bias imposes u34‐modified trnas highly metabolic melanomas unfavorable growth conditions require thiolated trnas accurate translation transfer rna anticodon anticodon loop interphase alternative codon usage mtorc2‐mediated phosphorylation posttranscriptional rna modifications resistant brafv600e melanoma united states government pmc disclaimer extreme environmental conditions modify transfer rna commonly mutated genes enhances elp1 phosphorylation sustain malignant properties
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