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Title[redir]:
KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners - PMC
Description:
Regulatory T cells (Tregs) are indispensable for the establishment of tolerance of self-antigens in animals. The transcriptional regulator Foxp3 is critical for Treg development and function, controlling the expression of genes important for Tregs ...
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Keywords {🔍}
tregs, kap, doi, mice, cells, foxp, cell, kapdeficient, figure, expression, pubmed, google, scholar, tregδkap, pmc, data, treg, genes, article, slca, free, function, proliferation, binding, hkme, development, analysis, regulatory, independent, control, transcriptional, shown, kapsufficient, protein, gene, mouse, experiments, chipseq, marks, analyzed, transcription, histone, antibody, days, expressed, zhou, figures, important, found, decreased,
Topics {✒️}
crossing foxp3-ires-yfp/cre mice specific pathogen-free facilities foxp3-ires-yellow fluorescent protein glutamine-free media displayed jmjd2a/c-mediated h3k9me3 marks satb1-dependent super-enhancer establishment glutamine-free rpmi medium treg-specific kap1-deficient mice 5 mg/ml anti-ifn-γ 1 mg/ml anti-cd28 numerous cell-cycle-related genes foxp3+yfp− kap1-sufficient counterpart mock-transduced kap1-deficient tregs anti-cd3/cd28 antibody anti-cd3/cd28 stimulation cd4+cd8+ double-positive cells pmc beta search goat anti-mouse igg anti-β-actin antibody pmscv-ires-cfp ii regulatory t-cell fate 5 mg/ml anti-il-4 antibody/protein/dna complexes anti-cd3/cd28 beads random x-chromosome inactivation pre-existent enhancer landscape krab-zinc finger proteins krab zinc-finger proteins human-specific adaptor fik larger cell-culture plate zinc-finger family members kap1-deficient extreg cd4+ 3 ng/ml tgf-β kap1/foxp3 complex affects anti-cd3/cd28 kap1-deficient tregs failed kap1/foxp3 complex functions cre-expressing mice kap1-deficient tregs transduced kap1-sufficient tregs responded tregδkap1 mice develop treg-specific deletion gene-proximal regulatory element cell-cycle-related genes rna-seq datasets reported treg-specific genes supplementary materials included kap1-mediated transcriptional regulation suv39h1-deficient th2 cells references allan rs
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