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Title[redir]:
Gender and outcomes in non-small cell lung cancer: an old prognostic variable comes back for targeted therapy and immunotherapy? - PMC
Description:
There are well-known differences in gender outcome in non-small cell lung cancer (NSCLC) and other cancers. In this work, we evaluated several randomised clinical trials to explore the gender influence in the outcome of patients with NSCLC treated ...
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Keywords {🔍}
cancer, patients, lung, doi, google, scholar, pubmed, female, inhibitors, chemotherapy, gender, egfr, women, male, versus, nsclc, trials, metaanalysis, data, pmc, cell, benefit, phase, nonsmall, article, nonsmallcell, differences, randomised, analysis, free, study, treatment, men, supplementary, figure, clinical, survival, advanced, iii, antipd, alk, genders, immune, response, firstline, oncol, targeted, therapy, evaluated, ascend,
Topics {✒️}
org/tools/review-production-tools/revman-5 online supplementary figures s2–s4 tyrosine kinase inhibitor anti-pd-l1 inhibitors showed pd-l1 tumour expression level ≥1% clinical practice points clinic-based screening programs small-cell lung cancer adopted fixed effects assumption favouring anti-pd1 inhibitors pmc beta search advanced egfr mutation-positive platinum-based doublet chemotherapy online supplementary figure s1 online supplementary figure s5 online supplementary figure s6 phase iii trials alk-positive lung cancer tumours bared alk rearrangements anti-immune checkpoint activity anti-pd1 inhibitors nivolumab prior platinum-based regimen anti-pd1 inhibitors compared pd-l1 protein expression evaluated anti-pd1 inhibitors alk-rearranged stage iiib phase iii trial phase iii study randomised clinical trials anti-pd-l1 blockade anti-pd-l1 durvalumab stages iiib–iv pfs anti-egfr tkis pd-l1 tumour expression iv squamous cell nsclc publisher site pdf sex-biased immune responses long-term survival outcomes population-based cohort study anti-pd1 inhibitors subsequent clinical trials favouring egfr inhibitors supplementary materials included anti-alk inhibitors platinum-based chemotherapy [google scholar] 2 pacific trial comparing atezolizumab versus docetaxel progression-free survival favouring alk inhibitors
Questions {❓}
- Are female smokers at higher risk for lung cancer than male smokers?
- Gender and outcomes in non-small cell lung cancer: an old prognostic variable comes back for targeted therapy and immunotherapy?
- How might this impact on clinical practice?
- Lung cancer: a biologically different disease in women?
- Sex-associated differences in non-small cell lung cancer in the new era: is gender an independent prognostic factor?
- What does this study add?
- What is already known about this subject?
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