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Keywords {🔍}

doi, dkk, fasudil, google, scholar, pubmed, daam, protein, synapse, aβo, wntpcp, spine, pmc, pathway, brain, hours, dendritic, wnt, disease, rock, loss, cell, free, fig, article, signaling, synaptic, control, effects, kinase, synaptotoxicity, cognitive, neuronal, cultures, alzheimers, dependent, levels, density, treated, blocked, psd, previously, dickkopf, data, activation, number, expression, vehicle, amyloid, rat,

Topics {✒️}

aβ-activated dkk1-wnt-pcp-daam1-rhoa/rock-dependent pathway α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid poly-d-lysine 10 μg/ml wnt-pcp/rhoa/rock pathway requires beta-amyloid-induced hippocampal neurodegeneration canonical wnt-β-catenin–signaling dkk1 wnt-pcp-daam1-rhoa/rock pathway glycogen synthase kinase-α/β c-jun n-terminal kinase f-actin–labeled puncta quantified high-performance liquid chromatography wnt-pcp-rhoa/rock pathway diaphanous-related formin daam1 mitogen-activated protein kinase 8 jnk/c-jun primarily wnt–planar cell polarity green/purple color scheme jun n-terminal kinase pmc beta search aβ-driven dkk1-dependent activation jnk/c-jun arm dkk1-induced spine losses dkk1-induced spine withdrawals wnt-pcp-jnk pathway post hoc t-test mrc grants mr/m013944/1 aβ/app-based mouse models dkk1-driven spine losses penetrating sirna duplexes aβ-driven synapse loss dkk1-driven synapse loss wnt-pcp underpins multiple amyloid-beta-induced dysregulation aβ-driven spine loss cadherin-catenin adhesion complexes aβ-induced cognitive impairment noncanonical wnt-signaling pathways dkk1-driven synapse retraction aβ-induced neuronal death dkk1-sirna duplex aβ activates wnt-pcp dkk1-wnt-pcp activity [4] regulates cytoskeletal dynamics dkk1-dependent spine loss aβo-induced cognitive impairment planar cell polarity developing blood-brain barrier glua1 linear density/10 μm c-abl oncogene 1 brain free fraction

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