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Title[redir]:
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway - PMC
Description:
We have revealed that a novel stress-inducible protein, Sestrin2, declines in the heart with aging. Moreover, there is an interaction between Sestrin2 and energy sensor AMPK in the heart in response to ischemic stress. The objective of this study is ...
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Keywords {🔍}
hearts, aged, sesn, doi, young, ampk, sestrin, postmi, ischemic, protein, levels, myocardial, heart, pgcα, pubmed, google, scholar, sham, cardiac, fig, impaired, pmc, ischemia, signaling, article, infarction, aging, mice, stress, activation, mitochondrial, left, conditions, free, coronary, sem, cell, artery, demonstrated, aavsesn, immunoblotting, values, means, versus, mitochondria, kinase, data, response, insults, measured,
Topics {✒️}
p-acetyl-coa carboxylase apoptosis-inducing factor amp-activated protein kinase mitochondrial transcription factor left ventricle superoxide dismutase dutp nick-end labeling ppar-γ coactivator-1α hypoxia-inducible factor 1α relative mitochondrial dna ppar-alpha fractional shortening averaged ejection fraction sesn2-ampk-pgc-1α pathway ampk-pgc-1α signaling cascade terminal deoxynucleotidyl transferase impaired ampk/pgc-1α signaling pgc-1α signaling cascades ampk regulates pgc-1α ejection fraction fraction shortening lv contractile functions malondialdehyde pgc-1α protein levels gene transcription amp kinase inf apoptosis proteins aif transmission electron microscope anti-apoptosis protein bcl-2 important factor responsible ampk downstream pgc-1α directs pgc-1α signaling rescued pgc-1α levels regulation pro-apoptosis protein cardiac pgc-1α levels oxidant-induced barrier dysfunction infarct area impaired pgc-1α levels nuclear dna sesn2-ampk signaling cascade pgc-1α signaling response impaired fs occurred prevents age-related pathologies ampk kinase dead dna damage cardiac sod activities hallmark age-related pathologies classic age-related pathologies left ventricular cavity
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- Echocardiographic measurement of left atrial volume: does the method matter?
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