
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension - PMC
Description:
Pulmonary hypertension (PH) complicates the care of patients with chronic lung disease, such as idiopathic pulmonary fibrosis (IPF), resulting in a significant increase in morbidity and mortality. Disease pathogenesis is orchestrated by unidentified ...
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Keywords {🔍}
doi, pulmonary, pubmed, google, scholar, cells, cxcr, lung, pmc, article, fibrosis, free, mice, cell, ipf, patients, bleomycin, vascular, mdscs, hypertension, disease, data, myeloidderived, clodronate, figure, gmdscs, expression, suppressor, gmdsc, mdsc, respir, remodeling, med, development, idiopathic, chemokine, blood, compared, receptor, increased, control, population, immune, inflammatory, macrophage, assessed, cxcl, care, chronic, increase,
Topics {✒️}
cd11b+cd33+hla-dr−cd14−cd15+ cells cd11b+cd33+hla-dr−cd14+ cells inhibit graft-versus-host disease myeloid-derived suppressor cell myeloid-derived suppressor cells liposome-treated wild-type mice anti-cd3/cd28 beads bleomycin-treated wild-type mice unidentified myeloid-derived cells macrophage inflammatory protein-1α α-smooth muscle actin granulocyte-colony–stimulating factor macrophage colony–stimulating factor progenitor myeloid-cell population endothelial bmpr-ii ccl2/ccr2 chemokine systems pulmonary bleomycin-induced injury pmc beta search pulmonary veno-occlusive disease tailed mann-whitney test hypoxia-induced pulmonary hypertension bleomycin-induced pulmonary inflammation antagonizing cxcr2-mediated trafficking mdsc-mediated pulmonary vascular normal wild-type control granulocytic mdsc [g-mdsc] infectious/inflammatory lung disease bleomycin-induced pulmonary fibrosis pmc copyright notice clodronate liposome–treated animals myeloid-derived cells chemokine receptor c-x g-mdscs function predominantly g-mdsc trafficking contributes g-mdsc cell population bleomycin-induced lung fibrosis decreasing g-mdsc recruitment gov/ct2/show/nct02138825 7 motif chemokine receptor tumor-induced tolerance bleomycin-clodronate–treated animals specific g-mdsc population prevent g-mdsc recruitment bd lsr ii clodronate/bleomycin–treated mice monocytic mdsc [mo-mdsc] alveolar epithelium protects publisher site pdf cd33+cd11b+ cells monocyte/macrophage lineage
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