NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC5777858/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC5777858/. The analysis below is for the second page.
Title[redir]:
NAD+ replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair - PMC
Description:
Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response to and repair of DNA double-strand ...
Title[redir]:
NAD+ replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair - PMC
Description:
Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response to and repair of DNA double-strand ...
Matching Content Categories {📚}
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Content Management System {📝}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
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Traffic Estimate {📈}
What is the average monthly size of ncbi.nlm.nih.gov audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
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How Does Ncbi.nlm.nih.gov Make Money? {💸}
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Keywords {🔍}
atm, worms, doi, fig, nad, dna, cells, pubmed, google, scholar, mitophagy, sirt, mice, levels, repair, neurons, atmkd, treatment, data, pmc, cell, lifespan, article, control, pathway, protein, free, mitochondria, proteins, srt, nature, increased, treated, figs, nmn, analysis, pathways, nhej, damage, effects, expression, olaparib, improved, aging, signaling, significantly, defects, dct, elegans, genes,
Topics {✒️}
reporter plasmid pegfp-pem1-ad2 high-fat diet-induced obesity atm-kd sh-sy5y cells supplemental experimental procedures approximately 570-590 mg/kg/day/mouse dna double-strand break serine/threonine protein kinase references bakkenist cj poly-adp-ribose polymerase 1 polyethyleneimine-coated plastic dishes kaplan-meier survival curves pmc beta search atm-kd sh-sy5ycells extended experimental procedures dna double-strand breaks nih/nia grant 5r37ag028730-09 sharing mt-mkeima plasmid mt-mkeima fluorescent reporter control sh-sy5y cells sprague-dawley rat embryos nmn-treated atm−/−mice compared sirt6 double-kd mutants myo-3∷gfp reporter gene atm-deficient primary neurons atm-kd neurons stained tailed unpaired t-test short-term associative memory apparent steady-state level sh-sy5y cells specific age-related pathologies dna repair-deficient diseases nad+-dependent sirt1 participates short-lived atm−/− mice short-lived atm-1 worms sex-matched wt littermates oxidase subunit iv flight mass spectrometry nad+/sirt1 signaling reduce long-term associative memory giving atm−/−male mice valentin-vega minor remaining benefits fernandez-marcos pj supplementary materials included nad+-induced lifespan extension nad+/sirt1 pathway contributes high fat diet hr repair-deficient mutants license information pmcid mt-mkeima-related imaging
Social Networks {👍}(6)
External Links {🔗}(105)
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