
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Dendrogenin A drives LXR to trigger lethal autophagy in cancers - PMC
Description:
Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor properties. Here, we explored its efficacy and mechanism of cell death in melanoma and acute myeloid leukemia (AML). We found that DDA induced lethal autophagy in ...
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Keywords {🔍}
dda, cells, fig, doi, cell, supplementary, autophagy, pubmed, lxrβ, google, scholar, aml, treated, human, analysis, mice, death, expression, data, pmc, melanoma, cancer, article, free, min, control, binding, lxr, tumor, tumors, skmel, activity, incubated, accumulation, cholesterol, pbs, lethal, induced, receptor, genes, vehicle, samples, transfected, experiments, cytotoxicity, protein, performed, autophagic, treatment, flow,
Topics {✒️}
ampk-skp2-carm1 signalling cascade nod/ltsz-scid il2rγc null gst-tagged ligand-binding domains caspase inhibitor z-vad-fmk specific pathogen-free conditions dda-induced mdc-labeled punctates 63x plan-apochromat objectif 3β-hydroxysterol-δ7-reductase streptavidin-biotin-peroxidase complex dako envision-peroxidase system annexin-v-7aad-negative cells distant-dependent dielectric term progenitor/leukemic stem cell dda-induced lc3-ii formation broad-spectrum therapeutic suppression hcd45+cd33+annexin-v- cells plasmid-expressing gfp-lc3 sds-page gels 50 μg/ml propidium iodide dr4-luciferase reporter plasmid caspase inhibitors z-vad flip-flop pharmacokinetic profile annexin-v-fluorescein isothiocyanate pmc beta search mutant braf-targeted therapies 50 µm z-vad-fmk long-lived protein degradation long-life protein degradation rxrbeta ligand-binding domains patient-derived aml xenografted induce lc3-ii expression tfeb promoter-luciferase construct flexible ligand-binding pocket surface markers cd45-v450 acid-precipitable cell fraction 50 µm z-devd-fmk include patient-derived xenografts de la recherche” 100 nm cis-retinoic acid human patient-derived aml potent anti-tumor activity broad anti-tumor activity acridine orange-positive vesicles anti-p62 guinea pig dda-induced cell death c17-induced cell death gfp-lc3-positive cells autophagy markers lc3-ii braf-mutated metastatic melanoma multilamellar body-derived lysosomes
Questions {❓}
- Ipilimumab combined with nivolumab: a standard of care for the treatment of advanced melanoma?
- Selective liver X receptor modulators (SLiMs): what use in human health?
- To be or not to be?
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