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Title[redir]:
An essential role for PNLDC1 in piRNA 3′ end trimming and male fertility in mice - PMC
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Keywords {🔍}
pnldc, figure, testes, supplementary, pirnas, information, pirna, mutant, rnas, small, miwi, pmc, mice, doi, mili, rna, longer, end, protein, reads, data, pubmed, article, line, pachytene, analysis, mutants, nlm, biogenesis, revealed, wildtype, miliassociated, mature, search, cell, precursors, mouse, spermatids, prepachytene, free, ncbi, primary, pathway, function, expression, type, showed, testis, spermatocytes, reduction,
Topics {✒️}
dna double-strand breaks quantitative rt-pcr showed extended base-pairing posed sense-strand exonic reads rt-pcr analysis revealed pmc beta search pre-pachytene pirna precursor embryonic/perinatal male germline pirna-guided line1 repression germ cell-specific small pnldc1-deficient pachytene spermatocytes [doi] [pubmed] aravin pnldc1-deficient elongated spermatids longer pre-pirnas/loss [doi] [pubmed] zheng long terminal repeat define meiotic defects publisher site pdf small rna analysis electron micrograph analysis electron microscopy analysis references saxe jp small rna reads primary pirna biogenesis total small rnas histological analysis revealed secondary biogenesis pathway pre-pachytene pirnas pirna pools generated rna species bound feed-forward loop independent studies identified excellent youth foundation ping pong pathway highly condensed chromatin longer rna species 3′ extended pre-pirnas sequence annotation revealed western blot analysis immunofluorescence analysis revealed united states government major organ tissues spermatogonial stem cells periodic acid-schiff early time point supplementary materials included primary pirna precursors transposon consensus revealed pnldc1 mutants correspond indicating severe defects
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