
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA - PMC
Description:
Bile salt hydrolase (BSH) activity against the bile acid tauro-beta-muricholic acid (T-β-MCA) was recently reported to mediate host bile acid, glucose, and lipid homeostasis via the farnesoid X receptor (FXR) signaling pathway. An earlier study ...
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Keywords {🔍}
doi, tβmca, bsh, johnsonii, activity, bile, google, scholar, pubmed, acid, lactobacillus, substrate, strains, pmc, nck, article, free, analysis, bshs, specificity, acids, atcc, bshc, data, fxr, amino, strain, identified, gut, pocket, intestinal, differences, interactions, binding, genome, site, assay, mrs, file, salt, mice, table, structure, hydrolase, ncc, microbiota, results, active, mouse, acidophilus,
Topics {✒️}
val57-ala58-asn59-asp60-tyr61-pro62-leu63 occludes phospholipid-depletion solid-phase extraction uplc-esi-qtofms-based screening assay alter t-β-mca concentrations intestinal t-β-mca concentrations t-β-mca ring structure uplc-esi-qtofms analysis tauro-beta-muricholic acid delta 22-beta-muricholic acid pmc beta search t-β-mca concentrations [7] n-terminal cysteine residues deconjugates t-β-mca deconjugating t-β-mca deconjugate t-β-mca intestinal t-β-mca mutated residues ser/asn108 including t-β-mca including t-β-mca [6 shine-delgarno site encoded uplc-esi-qtofms tauro-conjugated bile acids t-β-mca lastly t-β-mca activity primary bile acid t-β-mca concentration germ-free rats [google scholar] 42 cambridge university press delineating evolutionary relationships methods bacterial strains data availability statement bile salt hydrolase bile salt hydrolases advanced dental caries t-β-mca cysteine side chain liquid chromatography system conjugated muricholic acids conjugated bile acid dynamic models revealed license information pmcid aromatic side chain side-chain accuracy t-β-mca1 utilized predictive modeling maximum likelihood method full-scan mode funding statement wizard dna kit
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