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Title[redir]:
Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA - PMC
Description:
Methylglyoxal, a known endogenous and environmental mutagen, is a reactive α-ketoaldehyde that can modify both DNA and proteins. To investigate the possibility that methylglyoxal induces a crosslink between DNA and DNA polymerase, we treated ...
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Keywords {🔍}
methylglyoxal, dna, crosslink, google, scholar, pubmed, formation, doi, polymerase, kfexo, dnakfexo, incubated, crosslinks, induced, residues, glyoxal, reaction, template, min, fig, aclys, amino, crosslinking, form, shown, incubation, dgaclys, acids, acid, base, proteins, reacts, lys, detected, yield, involved, pmc, res, presence, mutations, nabh, biochem, primed, formed, mixture, open, nlm, guanine, singlestranded, derivatives,
Topics {✒️}
blunt-ended double-stranded dna n-acetyl-l-aspartic acid nα-acetyl-l-amino acids exonuclease-deficient klenow fragment nα-acetyl-l-asparagine nα-acetyl-l-arginine nα-acetyl-l-histidine nα-acetyl-l-tyrosine n-acetyl-l-tryptophan n-acetyl-l-alanine semicarbazide-sensitive amine oxidase n-acetyl-l-cysteine nα-acetyl-l-lysine β-dicarbonyl compound levels tsk-gel deae-2sw pmc beta search human serum albumins free amino acids methylglyoxal-induced dna–kfexo– crosslink dna–histone crosslinks induced dg–aclys crosslink derived age-related human diseases trans-2-pentenal induce crosslinks food mutagen 2-amino-3-methylimidazo dna-histone crosslinking induced dna–kfexo– crosslink increased crosslink single-stranded oligonucleotides dg–amino acid crosslink template dna-binding site dna–dna polymerase crosslinks dna–dna polymerase crosslink dg–aclys crosslink increased dg–aclys crosslink versus dna–kfexo– crosslink induced dg–accys crosslink increased dgmp–aclys crosslinks increased single-stranded-binding proteins bovine serum albumin t-2t/p-1 oligonucleotides potent crosslinking reagent t-1/p-1 ‘primed template irreversibly bound complexes klenow fragment bound lipid peroxidation system nucleic acids research observed dna–kfexo– crosslink dna–kfexo– crosslink formation advanced maillard reaction publisher site pdf single-stranded portion
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