
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Wilsonβs Disease in China - PMC
Description:
Wilsonβs disease (WD) is an autosomal recessive disorder of copper metabolism. Its incidence is higher in China than in western countries. ATP7B is the causative gene and encodes a P-type ATPase, which participates in the synthesis of ...
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Keywords {π}
doi, patients, google, scholar, disease, copper, atpb, pubmed, clinical, chinese, wilson, mutations, wang, wilsons, china, pmc, liver, chin, diagnosis, med, variants, study, neurological, mutation, yang, free, article, prl, diseasecausing, manifestations, degeneration, symptoms, brain, gene, treatment, hepatolenticular, found, therapy, function, cheng, pca, features, zhang, metabolism, cases, addition, level, common, analysis, nlm,
Topics {βοΈ}
decreased atp-binding affinity site-directed mutant variants pmc beta search susceptibility-weighted imaging manifestations multiplex allele-specific pcr black-brown copper particles broad-spectrum metal antidote short-term decoppering therapy placebo-controlled clinical trials uncertain long-term effects cost-effective genetic test susceptibility-weighted imaging free copper levels mild-moderate liver symptoms zhi-ying wu 1 publisher site pdf splice-site mutation giant glial cell common disease-causing variants license information pmcid autosomal recessive disorder copper-removal treatment heavy metal poisoning copper metabolism gene free copper long-term investigation extrapyramidal symptoms occur giant glial cells cellular copper tolerance continuously evolving process increasingly widely applied newly-synthesized apoceruloplasmin [41] valid adjuvant agent pre-symptomatic state apoplexy nerv dis mol cell neurosci van de sluis van oost ba yeast saccharomyces cerevisiae duff canning sj antioxid redox signal nervous mental dis copper metabolism domain liver damage manifests remediable hereditary disorder initiating oxidative damage superfluous copper accumulates low-copper diet chelates copper inside r992l mutants remain
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