
NCBI . NLM . NIH . GOV {
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Title[redir]:
Personalized Immunomonitoring Uncovers Molecular Networks That Stratify Lupus Patients - PMC
Description:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by breakdown of tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular heterogeneity, we longitudinally profiled the blood ...
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Keywords {🔍}
sle, doi, patients, figure, sledai, modules, blood, clinical, ifn, transcripts, treatment, pubmed, google, scholar, lupus, disease, analysis, module, pmc, plasmablast, signature, neutrophil, article, groups, data, signatures, patient, systemic, enrichment, transcriptional, free, response, samples, expression, correlated, pln, erythematosus, nephritis, cell, representing, stratification, immune, myeloid, molecular, correlates, panel, correlation, wgcna, set, mmf,
Topics {✒️}
anti-dsdna antibody titers pmc beta search interferon-alpha pathway identifies targeted cost-efficient bioassay circulating anti-dsdna antibodies cross-validation analysis ranged references arbuckle mr module/trait correlation matrix ugarte-gil garcia-romo batch-corrected expression datasets activated cd62l-low annotated interferon-regulated genes anti-dsdna antibodies supplementary materials included african-american patients respond expressed ifn-inducible transcripts systemic lupus erythematosus race-matched healthy controls supplemental experimental procedures achieve primary endpoints ifn-inducible gene quantitative set analysis medical center dallas leveraged weighted gene ingenuity pathway analysis numerous ifn-regulated transcripts license information pmcid interindividual correlation matrix modular transcriptional analysis anti-proliferative effect pro-inflammatory mediators extracellular dna degradation pro-inflammatory cytokines higher systemic inflammation pmc disclaimer myeloid lineage/neutrophil modules improve trial design suppress activated lymphocytes longitudinal correlation analyses data-driven approaches blood module space publisher site pdf principal component analysis follow clinical trait conducted modular analysis blood transcriptional profiles low baseline levels introduction sle discussion sle
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