NCBI . NLM . NIH . GOV {
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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC5288164/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC5288164/. The analysis below is for the second page.
Title[redir]:
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma - PMC
Description:
Serine-glycine biosynthetic pathway diverts the glycolytic intermediate 3-phosphoglycerate to synthesize serine and glycine, of which the latter was found to correlate with cancer cell proliferation. Increased de novo biosynthesis of glycine by ...
Title[redir]:
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma - PMC
Description:
Serine-glycine biosynthetic pathway diverts the glycolytic intermediate 3-phosphoglycerate to synthesize serine and glycine, of which the latter was found to correlate with cancer cell proliferation. Increased de novo biosynthesis of glycine by ...
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Keywords {🔍}
cells, shmt, cell, huh, glycine, doi, cancer, figure, tumor, data, shmtknockdown, pubmed, google, scholar, growth, pmc, metabolic, serineglycine, expression, effect, dox, serine, mice, article, proliferation, overexpression, methf, seeded, metabolism, supplementary, free, found, knockdown, control, gldc, thle, represent, experiments, incubated, medium, protein, microplate, formation, tumorigenicity, days, tumorigenesis, pathway, liver, hepg, genes,
Topics {✒️}
rapidly-proliferating lox imvi quantitative real-time pcr shmt2-knockdown remained unchanged shmt2-knockdown huh-7 cells pmc beta search rapidly-proliferating cancer cells shmt2-overexpressed huh-7 cells shmt2-overexpressed thle2 cells serine-glycine biosynthetic pathway myc-regulated metabolic enzymes site-specific metabolic phenotypes inducible shmt2 knockdown shmt2-overexpressed cells remains serine-glycine metabolic genes shmt2-knockdown hepg2 cells shmt2-mediated enzymatic reaction genomic instability caused inducible shmt2 inhibition control cells indicating methf-supplemented huh-7 cells supplementary materials oncotarget-07-53005-s001 serum-free medium license information pmcid dmem/f12 medium supplemented stable shmt2 knockdown shmt2-knockdown cells incubated supplementary figure 1a–1b black/clear bottom microplate serine-glycine inter-conversion [23] de novo biosynthesis control huh-7 cells shmt2-knockdown increased form tumor xenograft huh-7 cell lines mouse model doxycycline-added drinking water lung cancer cells generate tumor xenograft 3-fold higher level increasing glycine uptake shmt2-knockdown cells huh-7 cell growth cell death dis ultra-low attachment microplate nicotinamide adenine dinucleotide 12% sds/page gel metabolite profiling identifies conditions glioblastoma cells shmt2-overexpressed cells quantitative rt-pcr
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