
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Target Cell Cyclophilin A Modulates Human Immunodeficiency Virus Type 1 Infectivity - PMC
Description:
The peptidyl-prolyl isomerase cyclophilin A (CypA) increases the kinetics by which human immunodeficiency virus type 1 (HIV-1) spreads in tissue culture. This was conclusively demonstrated by gene targeting in human CD4+ T cells, but the role of ...
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Keywords {π}
cypa, cells, hiv, csa, doi, pubmed, google, scholar, fig, virus, virions, cell, human, virion, cyclophilin, hela, pmc, infectivity, type, interaction, immunodeficiency, article, target, free, effect, production, infection, replication, mutant, protein, produced, jurkat, binding, expression, virol, gag, activity, effects, wildtype, luban, restriction, results, producer, ref, cacypa, infectious, control, drug, sanglifehrin, presence,
Topics {βοΈ}
vsv-g-pseudotyped hiv-1-gfp vectors vsv-g-pseudotyped hiv-1 vectors vsv-g-pseudotyped virions produced anti-p24 monoclonal 183-h12-5c restricts n-tropic mlv csw-ntcypa/r55a transducing vector rd1-conjugated anti-p24 antibody mlv-based vector delivering n-tropic mlv vectors titrating n-tropic vlps hiv-1-gfp transducing vectors wild-type hiv-1nl4-3 virions virus-based shrna vector full-length infectious hiv-1 n-tropic mlv titer cell-type-specific response b-tropic mlv vlps rabbit polyclonal anti-cypa pmc beta search human t-cell lines 4% formaldehyde-phosphate-buffered saline n-terminal 283-residue fragment active-site mutant r55a produce cypa-transducing vectors 45-ΞΌm-pore-size filter pmc copyright notice n-tropic mlv gov/genome/seq/hsblast wild-type hiv-1nl4-3 cell-type-specific phenotypes peptidyl-prolyl isomerase cyclophilin vesicular stomatitis virus cell-type-specific effects wild-type hiv-1 vlps direct protein-protein interactions simian immunodeficiency virus cyclophilin-binding compounds isolated single-cycle replication assays hiv-1 cyclophilin-binding site ca-specific restriction factors hiv-1nl4-3 g89v mutant nl4-3/a92e reflects sensitivity essential cyclophilin-gag interaction ca chimera nl4-3/ca9 murine leukemia virus ca chimera nl4-3/mvp5180 hiv-1 ca/g89v vlps full-length virus disrupt ca-ca interactions nl4-3/g89v virus produced
Questions {β}
- How does CsA disrupt the production of infectious virions?
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