
NCBI . NLM . NIH . GOV {
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Title[redir]:
Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke - PMC
Description:
Concern about intracerebral hemorrhage (ICH) is the primary reason for withholding tPA therapy from patients with ischemic stroke. Early blood brain barrier (BBB) damage is the major risk factor for fatal post-thrombolysis ICH, but rapidly assessing ...
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Keywords {🔍}
occludin, blood, mcao, ischemic, bbb, stroke, levels, damage, doi, cerebral, pubmed, google, scholar, ischemia, hour, protein, hours, reperfusion, early, onset, kda, pmc, brain, rats, microvessels, article, tpa, increase, barrier, liu, fragments, level, patients, min, increased, data, mmp, free, leakage, claudin, fig, bloodbrain, risk, loss, evans, blue, duration, biomarkers, thrombolysis, time,
Topics {✒️}
blood-brain barrier/neurovascular unit matrix metalloproteinase-mediated disruption tissue plasminogen activator blood-brain barrier breakdown blood-brain barrier permeability pmc beta search blood-brain barrier damage enzyme-linked immunosorbent assay form dynabeads-ab complex additional information blood brain barrier blood-brain barrier methods rat model 4 ml ice-cold pbs license information pmcid magnetic resonance imaging tight junction proteins cerebral ischemia induces 5-hour post-ischemia onset fatal post-thrombolysis ich identify high-risk patients cerebral ischemia induced evans blue leakage vegfr-2-dependent manner publisher site pdf higher mmp-9 levels blood occludin increases tight junction protein impending hemorrhagic transformation ischemic hemispheric tissue ischemic brain injury clinical deterioration caused elevated peripheral neutrophils complicated tight junctions29 early exercise protects focal cerebral ischemia 5-hour mcao induced time dependent pattern carotid artery atherosclerosis blood occludin level ischemic brain regions entire ischemic brain blood occludin levels significant blood flow key structural component dynabeads-ab complex 41-μm nylon mesh references kleindorfer early stroke stage cerebral ischemia generated
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