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Keywords {🔍}

mice, gdf, mitochondrial, mko, muscle, doi, pubmed, google, scholar, fig, insulin, expression, skeletal, glucose, free, pmc, article, metabolic, kim, resistance, weight, liver, hfd, chop, control, cells, uprmt, oxphos, fed, group, data, cell, obesity, levels, ctrl, stress, elevated, function, adipose, male, factor, systemic, activity, body, tissue, gene, wkold, ewat, rgdf, energy,

Topics {✒️}

million fragments mapped carbon dioxide production extensor digitorum longus putative chop-responsive elements respiratory exchange ratio oxygen consumption rate dpni-based site-directed mutagenesis ob/ob c57bl/6j lep n-dodecyl-β-d-maltoside lentivirus-delivered chop-specific shrna high-fat diet-induced obesity white adipose tissue muscle-specific crif1 lof mtdna mutator mice individual time-matched vehicle-treated phospho–p38 t180/y182 expression growth/differentiation factor-15 free fatty acid double gdf15−/−mko-knockout mice oxygen consumption insulin tolerance test double fgf21−/−mko–knockout mice nag-1/gdf-15 prevents obesity pmc beta search tissue-specific loss vehicle-treated ob/ob mice muscle-specific knockout [mko] rgdf15-treated ob/ob mice gdf15-treated ob/ob mice double-knockout mice generated 100-nt paired-end sequencing mitochondrial gene set tgf-β reversible inhibitor tissue-specific glucose metabolism crif1-deficient mef cells fatty acid oxidation kpni–xhoi-digested pgl3basic family-wise error rate m-mlv reverse transcription intraperitoneal glucose challenge high-fat diet motor-driven teflon pestle principal-component analysis plot tgf-beta superfamily amp-activated protein kinase tgf-β ligand family improves glucose tolerance fragments crif1 lof leads pmc copyright notice

Questions {❓}

• Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?
• Growth/differentiation factor-15: prostate cancer suppressor or promoter?
• Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans?

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• Learn how profitable https://scholar.google.com/scholar_lookup?journal=Science&title=Rates%20of%20behavior%20and%20aging%20specified%20by%20mitochondrial%20function%20during%20development&author=A.%20Dillin&author=A.L.%20Hsu&author=N.%20Arantes-Oliveira&author=J.%20Lehrer-Graiwer&author=H.%20Hsin&volume=298&publication_year=2002&pages=2398-2401&pmid=12471266&doi=10.1126/science.1077780& is on a monthly basis
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• What's the revenue for https://doi.org/10.1371/journal.pone.0034868?
• Profit of https://scholar.google.com/scholar_lookup?journal=PLoS%20One.&title=Macrophage%20inhibitory%20cytokine%201%20(MIC-1/GDF15)%20decreases%20food%20intake,%20body%20weight%20and%20improves%20glucose%20tolerance%20in%20mice%20on%20normal%20and%20obesogenic%20diets&author=L.%20Macia&author=V.W.%20Tsai&author=A.D.%20Nguyen&author=H.%20Johnen&author=T.%20Kuffner&volume=7&publication_year=2012&pages=e34868&pmid=22514681&doi=10.1371/journal.pone.0034868&
• https://doi.org/10.1038/cdd.2008.166's total income per month
• Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Cell%20Death%20Differ.&title=Mitochondrial%20dysfunction%20triggered%20by%20loss%20of%20HtrA2%20results%20in%20the%20activation%20of%20a%20brain-specific%20transcriptional%20stress%20response&author=N.%20Moisoi&author=K.%20Klupsch&author=V.%20Fedele&author=P.%20East&author=S.%20Sharma&volume=16&publication_year=2009&pages=449-464&pmid=19023330&doi=10.1038/cdd.2008.166&
• What is the earnings of https://doi.org/10.2337/db06-S002?
• https://scholar.google.com/scholar_lookup?journal=Diabetes.&title=Molecular%20mechanisms%20of%20insulin%20resistance%20in%20humans%20and%20their%20potential%20links%20with%20mitochondrial%20dysfunction&author=K.%20Morino&author=K.F.%20Petersen&author=G.I.%20Shulman&volume=55&issue=Suppl.%202&publication_year=2006&pages=S9-S15&pmid=17130651&doi=10.2337/db06-S002&'s total income per month
• Explore the financials of https://doi.org/10.1016/j.molcel.2015.02.008
• How much money does https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell.&title=Mitochondrial%20and%20nuclear%20accumulation%20of%20the%20transcription%20factor%20ATFS-1%20promotes%20OXPHOS%20recovery%20during%20the%20UPR(mt)&author=A.M.%20Nargund&author=C.J.%20Fiorese&author=M.W.%20Pellegrino&author=P.%20Deng&author=C.M.%20Haynes&volume=58&publication_year=2015&pages=123-133&pmid=25773600&doi=10.1016/j.molcel.2015.02.008& generate?
• How much revenue does https://doi.org/10.1016/j.cell.2012.02.035 generate?
• What's the profit of https://scholar.google.com/scholar_lookup?journal=Cell.&title=Mitochondria:%20in%20sickness%20and%20in%20health&author=J.%20Nunnari&author=A.%20Suomalainen&volume=148&publication_year=2012&pages=1145-1159&pmid=22424226&doi=10.1016/j.cell.2012.02.035&?
• What is the earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem.&title=The%20general%20occurrence%20of%2055%20S%20ribosomes%20in%20mammalian%20liver%20mitochondria&author=T.W.%20O%E2%80%99Brien&volume=246&publication_year=1971&pages=3409-3417&pmid=4930061&?
• Find out how much https://doi.org/10.1016/j.molmet.2015.11.002 earns monthly
• How much does https://scholar.google.com/scholar_lookup?journal=Mol.%20Metab.&title=Muscle%20mitochondrial%20stress%20adaptation%20operates%20independently%20of%20endogenous%20FGF21%20action&author=M.%20Ost&author=V.%20Coleman&author=A.%20Voigt&author=E.M.%20van%20Schothorst&author=S.%20Keipert&volume=5&publication_year=2015&pages=79-90&pmid=26909316&doi=10.1016/j.molmet.2015.11.002& bring in each month?
• What is the monthly revenue of https://doi.org/10.1016/j.cell.2013.09.021?
• Profit of https://scholar.google.com/scholar_lookup?journal=Cell.&title=Muscle%20mitohormesis%20promotes%20longevity%20via%20systemic%20repression%20of%20insulin%20signaling&author=E.%20Owusu-Ansah&author=W.%20Song&author=N.%20Perrimon&volume=155&publication_year=2013&pages=699-712&pmid=24243023&doi=10.1016/j.cell.2013.09.021&
• How much does https://doi.org/10.1210/er.2009-0003 earn?
• How much money does https://scholar.google.com/scholar_lookup?journal=Endocr.%20Rev.&title=The%20role%20of%20mitochondria%20in%20the%20pathophysiology%20of%20skeletal%20muscle%20insulin%20resistance&author=I.%20Pagel-Langenickel&author=J.%20Bao&author=L.%20Pang&author=M.N.%20Sack&volume=31&publication_year=2010&pages=25-51&pmid=19861693&doi=10.1210/er.2009-0003& make?
• Profit of https://doi.org/10.1038/nature13818
• How much does https://scholar.google.com/scholar_lookup?journal=Nature.&title=Mitochondrial%20UPR-regulated%20innate%20immunity%20provides%20resistance%20to%20pathogen%20infection&author=M.W.%20Pellegrino&author=A.M.%20Nargund&author=N.V.%20Kirienko&author=R.%20Gillis&author=C.J.%20Fiorese&volume=516&publication_year=2014&pages=414-417&pmid=25274306&doi=10.1038/nature13818& bring in each month?
• How much money does https://doi.org/10.1016/j.cmet.2013.10.004 generate?
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Cell%20Metab.&title=Reversal%20of%20hypertriglyceridemia,%20fatty%20liver%20disease,%20and%20insulin%20resistance%20by%20a%20liver-targeted%20mitochondrial%20uncoupler&author=R.J.%20Perry&author=T.%20Kim&author=X.M.%20Zhang&author=H.Y.%20Lee&author=D.%20Pesta&volume=18&publication_year=2013&pages=740-748&pmid=24206666&doi=10.1016/j.cmet.2013.10.004&?
• What are the total earnings of https://doi.org/10.1126/science.aaa0672?
• What is the earnings of https://scholar.google.com/scholar_lookup?journal=Science.&title=Controlled-release%20mitochondrial%20protonophore%20reverses%20diabetes%20and%20steatohepatitis%20in%20rats&author=R.J.%20Perry&author=D.%20Zhang&author=X.M.%20Zhang&author=J.L.%20Boyer&author=G.I.%20Shulman&volume=347&publication_year=2015&pages=1253-1256&pmid=25721504&doi=10.1126/science.aaa0672&?
• Find out how much https://doi.org/10.1126/science.1082889 earns monthly
• Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Science.&title=Mitochondrial%20dysfunction%20in%20the%20elderly:%20possible%20role%20in%20insulin%20resistance&author=K.F.%20Petersen&author=D.%20Befroy&author=S.%20Dufour&author=J.%20Dziura&author=C.%20Ariyan&volume=300&publication_year=2003&pages=1140-1142&pmid=12750520&doi=10.1126/science.1082889&
• What's the revenue for https://doi.org/10.1016/j.cell.2007.08.047?
• Explore the financials of https://scholar.google.com/scholar_lookup?journal=Cell.&title=Targeted%20deletion%20of%20AIF%20decreases%20mitochondrial%20oxidative%20phosphorylation%20and%20protects%20from%20obesity%20and%20diabetes&author=J.A.%20Pospisilik&author=C.%20Knauf&author=N.%20Joza&author=P.%20Benit&author=M.%20Orthofer&volume=131&publication_year=2007&pages=476-491&pmid=17981116&doi=10.1016/j.cell.2007.08.047&
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• What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Eur.%20J.%20Med.%20Res.&title=GDF-15%20protects%20from%20macrophage%20accumulation%20in%20a%20mouse%20model%20of%20advanced%20atherosclerosis&author=M.R.%20Preusch&author=M.%20Baeuerle&author=C.%20Albrecht&author=E.%20Blessing&author=M.%20Bischof&volume=18&publication_year=2013&pages=19&pmid=23800095&doi=10.1186/2047-783X-18-19&?
• How much cash flow does https://doi.org/10.1371/journal.pone.0056719 have monthly?
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• How much does https://doi.org/10.1038/nrm3984 rake in every month?
• What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Mol.%20Cell%20Biol.&title=New%20roles%20for%20mitochondrial%20proteases%20in%20health,%20ageing%20and%20disease&author=P.M.%20Quir%C3%B3s&author=T.%20Langer&author=C.%20L%C3%B3pez-Ot%C3%ADn&volume=16&publication_year=2015&pages=345-359&pmid=25970558&doi=10.1038/nrm3984&?
• Profit of https://doi.org/10.1128/MCB.23.20.7230-7242.2003
• Learn how profitable https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell.%20Biol.&title=Myostatin%20signals%20through%20a%20transforming%20growth%20factor%20beta-like%20signaling%20pathway%20to%20block%20adipogenesis&author=A.%20Rebbapragada&author=H.%20Benchabane&author=J.L.%20Wrana&author=A.J.%20Celeste&author=L.%20Attisano&volume=23&publication_year=2003&pages=7230-7242&pmid=14517293&doi=10.1128/MCB.23.20.7230-7242.2003& is on a monthly basis
• Get to know https://doi.org/10.1016/j.cmet.2014.08.001's earnings
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• How much revenue does https://doi.org/10.1371/journal.pgen.1003356 bring in?
• How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20Genet.&title=Crif1%20deficiency%20reduces%20adipose%20OXPHOS%20capacity%20and%20triggers%20inflammation%20and%20insulin%20resistance%20in%20mice&author=M.J.%20Ryu&author=S.J.%20Kim&author=Y.K.%20Kim&author=M.J.%20Choi&author=S.%20Tadi&volume=9&publication_year=2013&pages=e1003356&pmid=23516375&doi=10.1371/journal.pgen.1003356& generate monthly?
• How much money does https://doi.org/10.1016/j.tem.2009.09.008 generate?
• What's the income of https://scholar.google.com/scholar_lookup?journal=Trends%20Endocrinol.%20Metab.&title=Does%20skeletal%20muscle%20oxidative%20stress%20initiate%20insulin%20resistance%20in%20genetically%20predisposed%20individuals?&author=D.%20Samocha-Bonet&author=L.K.%20Heilbronn&author=D.%20Lichtenberg&author=L.V.%20Campbell&volume=21&publication_year=2010&pages=83-88&pmid=19854062&doi=10.1016/j.tem.2009.09.008&?
• Discover the revenue of https://doi.org/10.1016/j.bcp.2012.09.012
• What's https://scholar.google.com/scholar_lookup?journal=Biochem.%20Pharmacol.&title=Pharmacological%20targeting%20of%20endoplasmic%20reticulum%20stress%20signaling%20in%20cancer&author=A.H.%20Sch%C3%B6nthal&volume=85&publication_year=2013&pages=653-666&pmid=23000916&doi=10.1016/j.bcp.2012.09.012&'s gross income?
• What's the total monthly financial gain of https://doi.org/10.1073/pnas.0506580102?
• Find out how much https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA.&title=Gene%20set%20enrichment%20analysis:%20a%20knowledge-based%20approach%20for%20interpreting%20genome-wide%20expression%20profiles&author=A.%20Subramanian&author=P.%20Tamayo&author=V.K.%20Mootha&author=S.%20Mukherjee&author=B.L.%20Ebert&volume=102&publication_year=2005&pages=15545-15550&pmid=16199517&doi=10.1073/pnas.0506580102& earns monthly
• Get to know https://doi.org/10.1016/S1474-4422(11)70155-7's earnings
• Learn how profitable https://scholar.google.com/scholar_lookup?journal=Lancet%20Neurol.&title=FGF-21%20as%20a%20biomarker%20for%20muscle-manifesting%20mitochondrial%20respiratory%20chain%20deficiencies:%20a%20diagnostic%20study&author=A.%20Suomalainen&author=J.M.%20Elo&author=K.H.%20Pietil%C3%A4inen&author=A.H.%20Hakonen&author=K.%20Sevastianova&volume=10&publication_year=2011&pages=806-818&pmid=21820356&doi=10.1016/S1474-4422(11)70155-7& is on a monthly basis
• How much money does https://doi.org/10.1038/nm.3699 generate?
• What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Nat.%20Med.&title=Niclosamide%20ethanolamine-induced%20mild%20mitochondrial%20uncoupling%20improves%20diabetic%20symptoms%20in%20mice&author=H.%20Tao&author=Y.%20Zhang&author=X.%20Zeng&author=G.I.%20Shulman&author=S.%20Jin&volume=20&publication_year=2014&pages=1263-1269&pmid=25282357&doi=10.1038/nm.3699&?
• Check the income stats for https://doi.org/10.1161/01.RES.0000256090.42690.05
• How much income does https://scholar.google.com/scholar_lookup?journal=Circ.%20Res.&title=AMP-activated%20protein%20kinase%20in%20metabolic%20control%20and%20insulin%20signaling&author=M.C.%20Towler&author=D.G.%20Hardie&volume=100&publication_year=2007&pages=328-341&pmid=17307971&doi=10.1161/01.RES.0000256090.42690.05& have?
• Earnings of https://doi.org/10.1093/bioinformatics/btp120
• What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Bioinformatics.&title=TopHat:%20discovering%20splice%20junctions%20with%20RNA-Seq&author=C.%20Trapnell&author=L.%20Pachter&author=S.L.%20Salzberg&volume=25&publication_year=2009&pages=1105-1111&pmid=19289445&doi=10.1093/bioinformatics/btp120&?
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• What's the financial gain of https://doi.org/10.1038/nature02517?
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• What's the monthly income of https://doi.org/10.1093/hmg/ddq310?
• See how much https://scholar.google.com/scholar_lookup?journal=Hum.%20Mol.%20Genet.&title=Mitochondrial%20myopathy%20induces%20a%20starvation-like%20response&author=H.%20Tyynismaa&author=C.J.%20Carroll&author=N.%20Raimundo&author=S.%20Ahola-Erkkil%C3%A4&author=T.%20Wenz&volume=19&publication_year=2010&pages=3948-3958&pmid=20656789&doi=10.1093/hmg/ddq310& makes per month
• https://doi.org/10.1016/S0014-5793(00)01914-1's revenue stream
• Explore the financials of https://scholar.google.com/scholar_lookup?journal=FEBS%20Lett.&title=Activin%20A%20increases%20Pax4%20gene%20expression%20in%20pancreatic%20beta%20cell%20lines&author=Y.%20Ueda&volume=480&publication_year=2000&pages=101-105&pmid=11034308&doi=10.1016/S0014-5793(00)01914-1&
• How profitable is https://doi.org/10.1038/pcan.2012.6?
• How much profit does https://scholar.google.com/scholar_lookup?journal=Prostate%20Cancer%20Prostatic%20Dis.&title=Growth/differentiation%20factor-15:%20prostate%20cancer%20suppressor%20or%20promoter?&author=P.%20Va%C5%88hara&author=A.%20Hampl&author=A.%20Kozub%C3%ADk&author=K.%20Sou%C4%8Dek&volume=15&publication_year=2012&pages=320-328&pmid=22370725&doi=10.1038/pcan.2012.6& generate?
• What's the financial gain of https://doi.org/10.1073/pnas.1509930112?
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA.&title=High-fat%20diet%20and%20FGF21%20cooperatively%20promote%20aerobic%20thermogenesis%20in%20mtDNA%20mutator%20mice&author=C.E.%20Wall&author=J.%20Whyte&author=J.M.%20Suh&author=W.%20Fan&author=B.%20Collins&volume=112&publication_year=2015&pages=8714-8719&pmid=26124126&doi=10.1073/pnas.1509930112&?
• What's the monthly money flow for https://doi.org/10.1126/science.272.5266.1347?
• What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Science.&title=Stress-induced%20phosphorylation%20and%20activation%20of%20the%20transcription%20factor%20CHOP%20(GADD153)%20by%20p38%20MAP%20Kinase&author=X.Z.%20Wang&author=D.%20Ron&volume=272&publication_year=1996&pages=1347-1349&pmid=8650547&doi=10.1126/science.272.5266.1347&?
• How much income is https://doi.org/10.1016/j.bcp.2012.11.025 earning monthly?
• https://scholar.google.com/scholar_lookup?journal=Biochem.%20Pharmacol.&title=The%20diverse%20roles%20of%20nonsteroidal%20anti-inflammatory%20drug%20activated%20gene%20(NAG-1/GDF15)%20in%20cancer&author=X.%20Wang&author=S.J.%20Baek&author=T.E.%20Eling&volume=85&publication_year=2013&pages=597-606&pmid=23220538&doi=10.1016/j.bcp.2012.11.025& income
• https://doi.org/10.18632/aging.100687's financial summary
• How much does https://scholar.google.com/scholar_lookup?journal=Aging%20(Albany,%20N.Y.).&title=hNAG-1%20increases%20lifespan%20by%20regulating%20energy%20metabolism%20and%20insulin/IGF-1/mTOR%20signaling&author=X.%20Wang&author=K.%20Chrysovergis&author=J.%20Kosak&author=G.%20Kissling&author=M.%20Streicker&volume=6&publication_year=2014&pages=690-704&pmid=25239873&doi=10.18632/aging.100687& gross monthly?
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• What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Biochem.%20Biophys.%20Res.%20Commun.&title=Respiratory%20chain%20dysfunction%20in%20skeletal%20muscle%20does%20not%20cause%20insulin%20resistance&author=A.%20Wredenberg&author=C.%20Freyer&author=M.E.%20Sandstr%C3%B6m&author=A.%20Katz&author=R.%20Wibom&volume=350&publication_year=2006&pages=202-207&pmid=16996481&doi=10.1016/j.bbrc.2006.09.029&?
• How much does https://doi.org/10.1016/j.cell.2014.07.039 bring in each month?
• What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Cell.&title=Multilayered%20genetic%20and%20omics%20dissection%20of%20mitochondrial%20activity%20in%20a%20mouse%20reference%20population&author=Y.%20Wu&author=E.G.%20Williams&author=S.%20Dubuis&author=A.%20Mottis&author=V.%20Jovaisaite&volume=158&publication_year=2014&pages=1415-1430&pmid=25215496&doi=10.1016/j.cell.2014.07.039&?
• https://doi.org/10.1161/01.RES.0000202804.84885.d0's revenue stream
• See how much https://scholar.google.com/scholar_lookup?journal=Circ.%20Res.&title=GDF15/MIC-1%20functions%20as%20a%20protective%20and%20antihypertrophic%20factor%20released%20from%20the%20myocardium%20in%20association%20with%20SMAD%20protein%20activation&author=J.%20Xu&author=T.R.%20Kimball&author=J.N.%20Lorenz&author=D.A.%20Brown&author=A.R.%20Bauskin&volume=98&publication_year=2006&pages=342-350&pmid=16397142&doi=10.1161/01.RES.0000202804.84885.d0& makes per month
• How much income does https://doi.org/10.1093/oxfordjournals.jbchem.a021798 have?
• What's the income of https://scholar.google.com/scholar_lookup?journal=J.%20Biochem.&title=Human%20cDNA%20encoding%20a%20novel%20TGF-beta%20superfamily%20protein%20highly%20expressed%20in%20placenta&author=M.%20Yokoyama-Kobayashi&author=M.%20Saeki&author=S.%20Sekine&author=S.%20Kato&volume=122&publication_year=1997&pages=622-626&pmid=9348093&doi=10.1093/oxfordjournals.jbchem.a021798&?
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• Revenue of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323
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• Monthly income for https://www.hhs.gov/
• How much does https://www.usa.gov/ pull in monthly?

Analytics and Tracking {📊}

• Google Analytics
• Google Analytics 4
• Google Tag Manager

Libraries {📚}

• jQuery
• jQuery module (jquery-3.6.0)
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• nihcesxway.hub.nih.gov
• nihcesxway2.hub.nih.gov
• nihcesxway3.hub.nih.gov
• nihcesxway4.hub.nih.gov
• nihcesxway5.hub.nih.gov

Name Servers:

• dns1-ncbi.ncbi.nlm.nih.gov
• dns2-ncbi.ncbi.nlm.nih.gov
• lhcns1.nlm.nih.gov
• lhcns2.nlm.nih.gov

CDN Services {📦}

• Ncbi