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Keywords {🔍}

degradation, brd, erk, protein, cells, tzthalidomide, figure, cliptac, doi, jqtco, probe, pubmed, google, scholar, protacs, target, pmc, click, treated, experiments, supplementary, article, ligase, reaction, free, chem, binding, levels, linker, thalidomide, crbn, ligand, hela, observed, molecules, addition, immunoblot, showing, actin, treatment, inhibitor, design, protac, heterobifunctional, bioorthogonal, covalent, approach, elicit, ligands, control,

Topics {✒️}

inverse-electron-demand diels–alder reactivity ras/raf/mek/erk signaling cascade trans-cyclo-octene-tagged protein ligands /webapps/site/bromodomain-assay-alphascreen trans-cyclo-octene tagged ligand targeting ras-erk signalling scaffolding/protein–protein interaction sites reaction biology corp liquid chromatography–mass spectrometry ymc-triart c18 column irdye800cw donkey anti-rabbit irdye680rd donkey anti-mouse pmc beta search methods lc-ms method extracellular signal–regulated kinases hetero-bifunctional protac intracellularly proteolysis targeting chimeras hard-won chemical probes tr-fret dilution buffer bio-orthogonal click reaction bio-orthogonal click combination bio-orthogonal combination reaction covalent tco-tagged inhibitor 2 nm tb-anti-patf2 x-ray crystal structure trans-cyclo-octene resulting bifunctional molecules reported bio-orthogonal reactions hetero-bifunctional molecule bioorthogonal small-molecule ligands hetero-bifunctional molecules alternative bio-orthogonal chemistry e3 ubiquitin ligase high molecular weight n-methylated tz-thalidomide 4 full experimental procedures small molecules targeting histone h4 peptide bifunctional small molecules overly short linker jq1-tco remained fixed e3 ubiquitin ligases bio-orthogonal reaction alphascreen binding assays license information pmcid polar surface area phospho-rsk protein levels clickable tetrazine moiety tco-tagged inhibitor small precursor molecules

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