
NCBI . NLM . NIH . GOV {
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Title[redir]:
The Researchers’ View of Scientific Rigor—Survey on the Conduct and Reporting of In Vivo Research - PMC
Description:
Reproducibility in animal research is alarmingly low, and a lack of scientific rigor has been proposed as a major cause. Systematic reviews found low reporting rates of measures against risks of bias (e.g., randomization, blinding), and a ...
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Keywords {🔍}
bias, research, reporting, participants, measures, google, scholar, doi, pubmed, guidelines, risks, animal, researchers, internet, scientific, rates, arrive, data, experimental, study, survey, knowledge, conduct, cited, published, table, ivsexp, sample, model, systematic, institutions, pmc, article, rigor, poor, docx, httpwwwncbinlmnihgovpubmed, models, reproducibility, nature, publication, primary, results, avoid, reviews, selfreports, validity, size, free, ivspub,
Topics {✒️}
artid=3720257&tool=pmcentrez&rendertype=abstract 10 artid=2779358&tool=pmcentrez&rendertype=abstract 10 artid=2893951&tool=pmcentrez&rendertype=abstract 10 gov/pmc/articles/pmc4320139/pdf/40064_2014_article_1534 /science/article/pii/s0006295215003585 10 cell biology/biochemistry/molecular biology uri=info%253adoi%252f10 pmc beta search peer-reviewed pharmacological literature data availability statement funding statement cancer molecular-marker research pre-clinical animal studies publisher site pdf org/article/fetchobject van der worp federal food safety multi-model inference [internet] license information pmcid bayesian information criterion harm-benefit analyses org/cgi/doi/10 org/lookup/doi/10 [google scholar] 45 [google scholar] 57 fully completed questionnaires data availability statements primary outcome variable discussion summary gov/pubmed/25674489\nhttp partially completed questionnaires uk/arrive-guidelines /authors/policies/reporting sample size calculation poor construct validity blinded outcome assessment usd 28b/year suitable correction rules valid clinical inference behavioral phenotyping enhanced ignoring reaction norms pmc disclaimer yielded identical results original data files life science articles additional data file supplementary materials included stepwise backwards procedure internal validity score united states government
Questions {❓}
- Believe it or not: How much can we rely on published data on potential drug targets?
- Can animal models of disease reliably inform human studies?
- Can the pharmaceutical industry reduce attrition rates?
- Do pressures to publish increase scientists’ bias?
- Environmental standardization: Cure or cause of poor reproducibility in animal experiments?
- How can we improve the pre-clinical development of drugs for stroke?
- Is animal research sufficiently evidence based to be a cornerstone of biomedical research?
- Reproducibility crisis: Are we ignoring reaction norms?
- Action?
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