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Keywords {🔍}

cells, mrea, doi, cell, figure, aging, pubmed, google, scholar, dna, expression, telomeric, pmc, article, patients, tissue, free, damage, protein, synovial, naïve, activity, repair, healthy, senescence, data, control, rheumatoid, arthritis, telomere, nuclei, cdkna, effector, telomeres, human, memory, weyand, nuclease, loss, goronzy, inflammation, heterochromatin, trf, satellite, measured, cdcdra, experiments, nature, induced, overexpression,

Topics {✒️}

supplementary material nihms820235-supplement double-strand break repair supplementary materials nihms820235-supplement pmc beta search dna-pkcs-jnk pathway human cd4+cd45ra+cd27- memory defining atm-independent functions signal-free end proliferation-induced telomeric shortening anti-p16 arc antibody long-lasting stem cell pro-athrogenic effector cells stem-cell ageing modified additional experimental procedures higher-order chromatin packaging classical pro-inflammatory cytokines pro-inflammatory effector cells p53-independent aging pathway sat-ii–specific probe anti-cd3/cd28 beads experimental procedures patients human end-differentiated effector signal-free ends pro-inflammatory cytokines tnf regulating joint-residing cells anti-inflammatory tissue environment tissue-injurious effector cells tissue-invading effector cells fish-probe hybridization patterns 53bp1/trf2 colocalization coefficients primary immune responses supplementary materials included resting naïve cd4+cd45ra+ oncogene-induced senescence nonhomologous end-joining end-differentiated cd4+cd28− arthritogenic effector functions sirna-mediated knockdown cell signaling technology terf2 sirna oligonucleotides higher-order unfolding repair dna damage telomeric damage induced transwell migration assays sousa-victor phase-specific recruitment transfecting healthy cd4+cd45ra+ mre11a sirna-treated cells gene transcriptional analysis similar proliferation rates

Questions {❓}

• Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

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