
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury - PMC
Description:
Using high-throughput screening we identified small molecules that suppress superoxide and/or H2O2 production during reverse electron transport through mitochondrial respiratory complex I (site IQ) without affecting oxidative phosphorylation ...
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Keywords {🔍}
sqels, site, doi, production, sqel, cell, superoxideho, cells, mitochondrial, figure, superoxide, pubmed, google, scholar, succinate, stem, activity, pmc, signaling, mitochondria, complex, article, oxidative, dehydrogenase, iiiqo, free, oxygen, brand, effect, stress, dmso, electron, astrocytes, drosophila, sites, inhibition, effects, respiration, assay, isolated, primary, data, injury, control, min, heart, ischemiareperfusion, values, means, orr,
Topics {✒️}
c-jun n-terminal kinase pmc beta search upstream nad-linked dehydrogenases supplemental experimental procedures directly damages iron-sulfur high-affinity site-specific suppressors cell metab summary ros-induced cell stress hold wide-ranging promise phospho-histone h3 high-throughput chemical screening manipulate superoxide-h2o2 production prevent superoxide-h2o2 production 12-hr light-dark cycle ischemia-reperfusion injury martin produce superoxide/hydrogen peroxide superoxide-h2o2 production specifically rat skeletal muscle cell-based phenotypic assay induce superoxide-h2o2 production license information pmcid suppress superoxide-h2o2 production outer ubiquinone-binding site mitochondrial superoxide-h2o2 production cardiac ischemia-reperfusion injury glucose-free dmem high-throughput screening strategy ischemia-reperfusion heart injury superoxide-h2o2-producing sites ins-1e insulinoma cells induced er stress atp synthase β supplementary materials included pressure transducer linked decreased superoxide-h2o2 production fluorescent amplex ultrared generates matrix superoxide generates superoxide-h2o2 identified n-cyclohexyl-4 stem cell proliferation fetal bovine serum vivo langendorff-perfusion model mitochondrial defect drives left ventricular pressure reverse electron transport enabling experimental dissociation alfred benzon foundation long maximum lifespan stem cell division triggers er stress
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