
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Direct GR binding sites potentiate clusters of TF binding across the human genome - PMC
Description:
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all ...
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Keywords {๐}
sites, binding, gbss, doi, dex, figure, activity, google, scholar, pubmed, cells, pmc, reporter, direct, genome, dna, motif, article, free, dexresponsive, regulatory, cell, gre, starrseq, bound, interactions, chipseq, gene, model, jund, treatment, peaks, analysis, beads, site, chromatin, dexinduced, library, clusters, human, receptor, response, data, tethered, number, treated, reads, expression, pcr, chip,
Topics {โ๏ธ}
org/packages/release/bioc/html/deseq2 bac-based dex-induced starr-seq gcโinduced chip starr-seq high-throughput paired-end sequencing chip-seq alignment files cell-type-specific gr binding chip-seq library construction a549-specific dex-inducible enhancers starr-seq input libraries starr-seq screening vector chip-reporter output libraries chip starr-seq-tss distances lacking dex-inducible activity chip starr-seq element starr-seq reporter assay cell-type-shared direct gbss [google scholar] ratman maximally pre-induced prior nuclear factor-kappab signaling long-range myb enhancers gr chip-seq counts dex-induced luciferase assays gr chip-seq libraries dose-specific coordinated manner sequence alignment/map format summed chip-seq signal fast gapped-read alignment pmc beta search tsc22d3 dex-inducible enhancer gc-inducible regulatory activity gr chip-seq signal starr-seq adapter primers anti-diabetic drug response chip-seq reflect interactions insulin-dependent diabetes mellitus tsc22d3 dex-induced enhancer dex-inducible reporter activity encode gc-responsive enhancers gr chip-exo signal illumina rna-seq libraries chip-seq signal aggregated glucocorticoid receptor-regulated promoter predict dex-induced genes chip-seq analysis methods binary gr/ap-1 interactions inter-chromosomal interactions correlate gc-mediated gene regulation normalized chip-reporter signal rna-2-ct cdna synthesis nearest dexโinduced gbs
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