
NCBI . NLM . NIH . GOV {
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Title[redir]:
The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus - PMC
Description:
The complex interplay between viral replication and host immune response during infection remains poorly understood. While many viruses are known to employ anti-immune strategies to facilitate their replication, highly pathogenic virus infections ...
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Keywords {🔍}
doi, genes, network, mice, infection, sarscov, kepi, expression, pubmed, pathogenesis, google, scholar, article, pmc, analysis, data, response, free, gene, studies, mouse, tnfα, important, study, weight, loss, signaling, results, previously, networks, centrality, host, infected, immune, additional, ccr, fig, effects, target, type, effect, coronavirus, virus, approach, apoptosis, respiratory, validation, approaches, wild, time,
Topics {✒️}
mers-cov severe sars-cov-induced disease 7 days post-infection 4 days post-infection 5–7 days post-infection knockout c-kinase-activated pp1 inhibitors acute lung injury tnf-alpha mouse-adapted sars-coronavirus protein-protein interaction networks protein phosphatase pp1 cellular protein phosphatase-1 network score values sars-cov-mediated lung pathogenesis clr score cutoff sars-cov-infected ace2+ cells day post-infection combinations single wgcna module targeting sars-cov-driven inflammation tnfα receptor signaling weighted gene protein phosphatase 1 limiting tnfα-driven inflammation mouse-adapted sars-cov tnfr-null mice tnfα receptor removal oxidants inhibit erk/mapk conducting sars-cov infections normal sars-cov infection murine sars-cov infection pmc beta search double-null tnfrsf1a/1b−/− mice sars coronavirus jason varying 103 pfu nf-kappab-mediated inflammation control sars-cov infection employ anti-immune strategies wgcna kme wild-type mice infected weighted networks influence sars-cov infection tnfα receptor 2 functional gene ontology log2 fold-change ratio alleviate sars-cov pathogenicity tnfrsf1a/1b−/− double ko cytokine receptor il1r1 chemokine receptor implicated time-matched control sample
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