
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Nfib promotes Metastasis through a Widespread Increase in Chromatin Accessibility - PMC
Description:
Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic progression remain poorly understood. We isolated pure populations of cancer cells from primary tumors and metastases from a genetically engineered mouse model ...
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Keywords {π}
nfib, doi, figure, cell, chromatin, sclc, regions, cells, accessibility, expression, sites, cancer, scholar, open, pubmed, google, metastatic, pmc, metastases, lines, article, nfi, tumors, free, gene, differentially, transcription, accessible, state, knockdown, nfibhigh, differential, ability, data, human, primary, samples, motif, lung, enriched, tumor, atacseq, progression, factor, factors, increased, occupancy, binding, fold, hyperaccessible,
Topics {βοΈ}
hakai-mediated e-cadherin degradation pmc beta search high-grade neuroendocrine carcinoma fluorescence-activated cell sorting small-cell lung cancer influence anchorage-independent growth lentiviral plko/puror vectors promoter-proximal chip peak pro-metastatic epigenetic states longest-lived transcription factors rna-seq sequencing data facs-purified sclc cells progression-free survival nfi/ctf gene family kp22-tre-empty cells initial atac-seq dataset atac-seq library preparation hormone-dependent chromatin remodeling hyper-accessible chromatin state pro-metastatic programs supplementary materials included rare liver macro-metastases largely gene-distal regions nfi sites genome-wide van meerbeeck slit/robo families higher-order nucleosome interactions nfi half-site motif hyper-accessible chromatin states promotes multiple steps atac-seq insertion tracks nih grant p50hg007735 large-scale chromatin accessibility atac-seq fragment sizes cre-reporter allele nfib-driven chromatin accessibility nfib-dependent metastatic progression atac-seq libraries hyper-accessible samples specifically license information pmcid steele-perkins de ruysscher dkm genome-wide footprinting nfib-positive liver metastases strong βfootprintingβ signal observed nfib-driven neuronal nfib chip-seq reads primary-tumor-enriched group human cell lines neuroendocrine lung carcinomas
Questions {β}
- Additivity in protein-DNA interactions: how good an approximation is it?
- Genome-wide footprinting: ready for prime time?
- How does Nfib establish an open chromatin architecture after binding?
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Analytics and Tracking {π}
- Google Analytics
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Libraries {π}
- jQuery
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Emails and Hosting {βοΈ}
Mail Servers:
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- dns1-ncbi.ncbi.nlm.nih.gov
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CDN Services {π¦}
- Ncbi