
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Epithelial-mesenchymal transition is associated with a distinct tumor microenvironment including elevation of inflammatory signals and multiple immune checkpoints in lung adenocarcinoma - PMC
Description:
Promising results in the treatment of NSCLC have been seen with agents targeting immune checkpoints, such as PD-1 or PD-L1. However, only a select group of patients respond to these interventions. The identification of biomarkers that predict ...
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Keywords {๐}
immune, lung, tumor, doi, cancer, adenocarcinoma, pdl, emt, expression, mesenchymal, cells, pubmed, google, scholar, epithelial, patients, pmc, microenvironment, prospect, article, clinical, free, molecules, checkpoint, nsclc, tcga, cell, mutational, data, response, study, gene, samples, including, multiple, protein, elevated, burden, tumors, high, fig, found, adenocarcinomas, versus, analysis, independent, resistance, rppa, dataset, ihc,
Topics {โ๏ธ}
anti-pd-1/pd-l1-directed therapy pd-l1/pd-l2 axes pd-l1/pd-l2 axis anti-pd-l1 antibody mpdl3280a pd-l1/pd-l2 pathway kras-mutant lung adenocarcinoma anti-pd-1/pd-l1 treatment versus e-cadherin rppa profound immune-related phenotypic early-stage lung adenocarcinoma multiple immune-stimulatory molecules microrna-200/zeb1 axis control pmc beta search nihโt32 research training anti-pd-1โdirected therapy dab-based colorimetric reaction immune-related gene list small-cell lung cancer received neo-adjuvant chemotherapy nci-funded lung spore mrna-based gene signature wild-type tp53 activate anti-tumor immunity micro-rna-dependent expression commonly-identified individual mutations programmed death-ligand 1 advanced stage/metastatic disease cells secreting ifn-ฮณ24 e-cadherin protein rppa ifn-ฮณ-induced protein 10 increased pd-l1 expression mutation-reactive immune response anti-pd-l1 antibody elevated ifn-ฮณ released array-based expression profiling pd-1/pd-l1 pathway chemotherapy-refractory metastatic disease pd-l1 expressing tumors pd-l1 protein expression dna/rna sequencing data core-needle biopsy specimens full tumor sections immune-related marker profiles biomarker-based clinical trial pd-l1 mrna levels ccr-15-1434 epithelial-mesenchymal transition recurrence free survival clin cancer res pd-l1 rppa correlated genomic mutational burden
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Analytics and Tracking {๐}
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