
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Epigenetic perturbations by Arg882-mutated DNMT3A potentiate aberrant stem cell gene expression program and acute leukemia development - PMC
Description:
DNA methyltransferase 3A (DNMT3A) is frequently mutated in hematological cancers; however, the underlying oncogenic mechanism remains elusive. Here, we report that DNMT3A mutational hotspot at Arg882 (DNMT3AR882H) cooperates with NRAS mutation to ...
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Keywords {π}
doi, dnmta, genes, figure, dnmtarh, meis, figures, hspcs, gene, scholar, aml, cell, pubmed, google, lscsrhras, expression, pmc, mutation, cpg, methylation, hypodmrs, article, cells, rhras, hkme, free, dnmtarhassociated, amls, dna, human, dotl, murine, leukemia, wang, activation, hoxa, relative, hkac, stemness, found, myeloid, stem, nature, blood, evras, sites, cancer, panel, binding, identified,
Topics {βοΈ}
mac-1+/c-kitlow/cd34low/gr1β/cd3eβ/cd19β/ter119β c-kitβ/mac-1high/f4β80high cd34β/c-kit+/linβ/scai+ hsc c-kit+/mac-1low/gr1β crispr/cas9-mediated enhancer editing crispr/cas9-mediated genomic editing crispr/cas9-mediated deletion b220+/cd19+ b-cell mll-af9-transformed aml cells pmc beta search rh-ras-induced aml development crispr/cas9-mediated ablation rh-ras-coexpressing cells derived ter119+/cd71+ erythroid cell independent lscrh-ras lines meis1-mn1-hoxa regulatory node histone h3-induced activation rh-ras versus ev-ras putative cis-regulatory sites chromatin-binding phd finger hematopoietic stem/progenitor cells confirmed sgc0946-mediated suppression cis-regulatory elements harbored rh-ras gave rise dnmt3a-null hscs display dnmt3a-mutated amls remain meis1-mn1-hoxa tf node oncogenic kras-induced leukemogeneis covalent histone modifications--miswritten distal cis-regulatory sites fine-tunes functional output rh-ras-induced leukemia rh-ras induced leukemia rh-ras immortalized cells οΏ½histone codeβ-dependent targeting treating dnmt3a-mutated leukemia arg882-mutated dnmt3a contributes lineage-specific dna methylation lscrh-ras stemness signature cpg-free reporter activated meis1-mn1-hoxa circuitry putative aml-promoting genes long-range looping interaction dnmt3ar882h chip-seq reads hypo-dmrs carrying h3k27ac dnmt3ar882h-mediated oncogenic effects supplementary materials included treat dnmt3a-mutated amls chip-seq data reported cells expressing rh-ras
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Analytics and Tracking {π}
- Google Analytics
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Libraries {π}
- jQuery
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Emails and Hosting {βοΈ}
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- dns1-ncbi.ncbi.nlm.nih.gov
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CDN Services {π¦}
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