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Title[redir]:
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes - PMC
Description:
To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of purified CD4+ T cells and monocytes, representing adaptive and innate immunity, in a ...
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Keywords {🔍}
cell, doi, table, genes, supp, nihmssupplementsupptabletsv, tsv, ciseqtls, pmc, monocytes, fig, cells, expression, article, types, google, scholar, effects, populations, free, pubmed, gene, shared, variants, snps, type, diseases, effect, trait, significant, ciseqtl, data, nlm, human, susceptibility, disease, supplementary, tables, genet, eqtl, study, diseaseassociated, eqtls, role, materials, proportion, participants, snp, ncbi, search,
Topics {✒️}
supplementary materials nihms788828-supplement-supplementary_materials org/content/344/6183/519/suppl/dc1 materials cell–specific cis-regulatory effects expression-level variance explained conservative bonferroni-corrected threshold expression-level fold-change cell type–specific cis-eqtls cross-population mapping allowed pmc beta search short-lived cell population cell type–dependent manner [google scholar] 14 top single-nucleotide polymorphism aging-related neurodegenerative diseases supplementary materials included context-specific cis-eqtl population-specific cis-eqtls tcell–specific cis-eqtls trans-eqtl meta-analysis transcription start site eu-specific cis-eqtl purified primary cells significant cis-eqtls shared cis-regulatory effects significant cis-eqtls detected nih f32 fellowship license information pmcid supplementary materials context-specific cis population-specific modulation population-level differences obtain similar estimates environment-linked variation cis-eqtl effects cross-population sharing neurodegenerative risk alleles bayesian hierarchical model discordant directional effects united states government final edited form hyun-il paik 5 multi-ethnic cohort effector/memory pools [false discovery rate distinguish coincidental colocalizations inherent logistic challenges increasingly diverse matrix include susceptibility alleles candidate causal variants significant cis-eqtl
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