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Title[redir]:
Ribosome heterogeneity in tumorigenesis: the rRNA point of view - PMC
Description:
The "specialized ribosome" concept proposes that ribosome variants are produced and differentially regulate translation. Examples supporting this notion demonstrated heterogeneity of ribosomal protein composition. However, ribosome translational ...
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Keywords {๐}
rrna, translational, cancer, ribosome, translation, pmc, ribosomes, omethylation, fbl, rna, doi, pmid, google, scholar, tumorigenesis, httpdxdoiorg, pubmed, nlm, cell, article, modification, methylation, ribosomal, activity, expression, cells, ncbi, search, site, control, modifications, pattern, free, heterogeneity, fibrillarin, composition, proteins, tumor, rrnas, mrna, chemical, specialized, demonstrated, protein, gene, human, support, studies, igfr, nature,
Topics {โ๏ธ}
rna-polymerase-i-dedicated modification endogenous igf-1r mrna pmc beta search igf-1r mrna translation conserved methyl-transferase guided de-pseudo-uridylate rrna alters ires-dependent translation rrna 2โฒ-o-methylation pattern [google scholar] 7 igf-1r ires ensure site specificity publisher site pdf ribosomal protein composition 2'-o-methylation pattern protein synthesis level enhances rna pol license information pmcid short hairpin rna rrna chemical modifications rrna 2'-o-methylation drosophila 80s ribosome chemical modifications identified united states government translation 40ย years ago efficiently initiate translation amino acid misincorporation stop codon read rrna domains critical key questions remain center lรฉon bรฉrard ribosome composition result healthy cells ribosomal protein support regulatory events cellular malignant phenotype pmc disclaimer tumor suppressor phosphatase favors tumor initiation rrna composition reduces favor tumor development selected additional rps affect rrna function 2โฒ-o-methylation sites express higher levels rrna pseudo-uridylation possesses anticancer activity ribosome translational activity jean-jacques diaz 1 fbl-dependent manner increased cancer susceptibility
Questions {โ}
- 6 However, several key questions remain to be addressed, including โAre rRNA chemical modifications heritable?
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