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Title[redir]:
Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism - PMC
Description:
Human CD4 T cells are constantly exposed to IL-12 during infections and certain autoimmune disorders. The current paradigm is that IL-12 promotes the differentiation of naïve CD4 T cells into Th1 cells, but recent studies suggest IL-12 may play a ...
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Keywords {🔍}
cells, human, tcr, activated, cytokine, production, fig, data, cell, pubmed, google, scholar, pretreated, stimulation, ifnγ, cytokines, doi, epub, pretreatment, expression, shown, untreated, donors, signaling, pmc, anticd, activation, stimulated, increased, article, free, antibodies, ngml, tnfα, antitcr, exposure, treated, effects, studies, clone, phosphorylation, determined, tcrinduced, metabolism, okt, eps, sem, immunology, increase, inflammatory,
Topics {✒️}
poly-l-lysine-coated xf-96 plates bead-bound anti-tcr/cd28 antibodies poly-l-lysine-coated plates plate-bound anti-tcr antibodies plate-bound anti-tcr anti-cd4 clone rpa-t4 tcr-induced ifn-γ production anti-cd3 clone okt3 anti-cd3 okt3 clone c-terminal src kinase drug-induced mitochondrial stress anti-tcr/cd28 antibodies pmc beta search real-time rt-pcr kinases tbk1-ikkvarepsilon supports isotype-matched control antibody tumor necrosis factor-alpha quantitative real-time pcr real-time quantitative pcr anti-src py416 antibody anti-plc-γ1 py783 tcr-induced signaling molecules pi-3 kinase/akt pathway augment tcr-induced il-4 supporting information files crosslinked anti-tcr/cd4 influences t-cell activation mrna encoding β-actin anti-p38 pt180/y182 fitc anti-ifn-γ measurable ifn-γ production increased tcr-induced phosphorylation il-12-mediated tumor suppression glucose free-medium glucose free medium murine effector/memory cd8 unknown post-transcriptional mechanism data availability statement il-12-induced immune responses funding statement cytokine-mediated programmed proliferation enhance ifn-γ production subunits il-12r β1 induce primarily ifn-γ maximal ifn-γ production tlr5 ligand increases il-12-induced il-10 production license information pmcid adhesion receptors cd2 cell receptor-mediated phosphorylation
Questions {❓}
- Our findings highlight a critical question: what is the physiological role of the potentiation of cytokine release by IL-12?
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