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Keywords {🔍}

mice, cell, cells, hscs, pubmed, google, scholar, doi, fig, stem, hsc, clps, aging, hematopoietic, lymphoid, differentiation, group, pmc, article, treated, experiments, analysis, free, restriction, independent, lymphopoiesis, response, cycle, progenitor, nature, effects, activity, quiescence, suppression, proliferation, lymphoidbiased, diet, data, expression, time, igf, lineage, prob, genes, facs, biolegend, number, myeloid, capacity, study,

Topics {✒️}

il-7rα+flt3+c-kitmid/lowsca-1mid/low lineage− cells il-7rα+flt3+c-kitmid/lowsca-1mid/lowlineage− cells quantitative real-time pcr megakaryocyte/erythrocyte progenitors granulocyte/macrophage progenitors ad libitum c-kitmid/lowsca-1mid/lowlineage− cells cd150+cd34−c-kit+sca-1+lineage− bm cells cd16/32−cd34+c-kit+sca-1−lineage− cells cd16/32−cd34−c-kit+sca-1−lineage− cells cd16/32+cd34+c-kit+sca-1−lineage− cells pe-cy7–conjugated anti–c-kit apc-conjugated anti–c-kit antibody real-time pcr c-kit+sca-1+lineage− bm cells promote hematopoietic-stem-cell-based regeneration pe-cy7–conjugated anti-sca-1 antibodies common myeloid progenitors common lymphoid progenitors refeeding [rf] pacific blue–conjugated anti–sca-1 apc-conjugated anti–c-kit c-kit+sca-1−lineage− cells pe-cy7–conjugated anti-cd16/32 pe-cy7–conjugated anti–sca-1 aggravating graft-versus-host disease apc-cy7–conjugated anti-cd19 pe-cy7–conjugated anti-cd48 pacific blue–conjugated anti-b220 pe-conjugated anti–sca-1 antibodies adrenalectomy qrt-pcr analysis apc-cy7–conjugated anti-cd11b pe-conjugated anti-flt3 pe-conjugated anti–sca-1 fitc-conjugated anti-cd16/32 pe-conjugated anti-cd150 fitc-conjugated anti-ki67 antibody apc-conjugated anti-cd150 b220+ter-119−gr-1−cd11b−cd3− cells qrt-pcr pe-conjugated anti-cd43 pe-conjugated anti-cd71 pe-conjugated anti-cd24 hematopoietic progenitor cells fitc-conjugated anti-cd24 pe-conjugated anti-b220 apc-conjugated anti-aa4 fitc-conjugated anti–gr-1 anti-apc magnetic beads

Questions {❓}

• Does caloric restriction extend life in wild mice?
• The ageing immune system: is it ever too old to become young again?

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• What is the earnings of https://scholar.google.com/scholar_lookup?journal=PLoS%20One.&title=Calorie%20restriction%20decreases%20murine%20and%20human%20pancreatic%20tumor%20cell%20growth,%20nuclear%20factor-%CE%BAB%20activation,%20and%20inflammation-related%20gene%20expression%20in%20an%20insulin-like%20growth%20factor-1-dependent%20manner&author=A.E.%20Harvey&author=L.M.%20Lashinger&author=D.%20Hays&author=L.M.%20Harrison&author=K.%20Lewis&volume=9&publication_year=2014&pages=e94151&pmid=24804677&doi=10.1371/journal.pone.0094151&?
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• What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Metabolism.&title=Effects%20of%20acute%20caloric%20restriction%20compared%20to%20caloric%20balance%20on%20the%20temporal%20response%20of%20the%20IGF-I%20system&author=P.C.%20Henning&author=D.E.%20Scofield&author=K.R.%20Rarick&author=J.R.%20Pierce&author=J.S.%20Staab&volume=62&publication_year=2013&pages=179-187&pmid=22906764&doi=10.1016/j.metabol.2012.07.004&?
• Profit of https://doi.org/10.1038/324073a0
• https://scholar.google.com/scholar_lookup?journal=Nature.&title=Complementary%20DNA%20for%20a%20novel%20human%20interleukin%20(BSF-2)%20that%20induces%20B%20lymphocytes%20to%20produce%20immunoglobulin&author=T.%20Hirano&author=K.%20Yasukawa&author=H.%20Harada&author=T.%20Taga&author=Y.%20Watanabe&volume=324&publication_year=1986&pages=73-76&pmid=3491322&doi=10.1038/324073a0&'s revenue stream
• How much profit is https://scholar.google.com/scholar_lookup?journal=Int.%20J.%20Vitam.%20Nutr.%20Res.&title=Dietary%20restriction%20augments%20erythropoiesis%20in%20mice&author=K.%20Hishinuma&author=S.%20Kimura&volume=60&publication_year=1990&pages=379-382&pmid=2101830& making per month?
• https://doi.org/10.1038/nature02994's total income per month
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Nature.&title=Gfi-1%20restricts%20proliferation%20and%20preserves%20functional%20integrity%20of%20haematopoietic%20stem%20cells&author=H.%20Hock&author=M.J.%20Hamblen&author=H.M.%20Rooke&author=J.W.%20Schindler&author=S.%20Saleque&volume=431&publication_year=2004&pages=1002-1007&pmid=15457180&doi=10.1038/nature02994&?
• https://doi.org/10.1038/nature01298 income
• How much does https://scholar.google.com/scholar_lookup?journal=Nature.&title=IGF-1%20receptor%20regulates%20lifespan%20and%20resistance%20to%20oxidative%20stress%20in%20mice&author=M.%20Holzenberger&author=J.%20Dupont&author=B.%20Ducos&author=P.%20Leneuve&author=A.%20G%C3%A9lo%C3%ABn&volume=421&publication_year=2003&pages=182-187&pmid=12483226&doi=10.1038/nature01298& pull in monthly?
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• What's the income of https://doi.org/10.1038/ncb0511-506?
• Financial intake of https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol.&title=Emerging%20models%20and%20paradigms%20for%20stem%20cell%20ageing&author=D.L.%20Jones&author=T.A.%20Rando&volume=13&publication_year=2011&pages=506-512&pmid=21540846&doi=10.1038/ncb0511-506&
• What's the income generated by https://doi.org/10.1038/nm1578 each month?
• https://scholar.google.com/scholar_lookup?journal=Nat.%20Med.&title=Telomere%20dysfunction%20induces%20environmental%20alterations%20limiting%20hematopoietic%20stem%20cell%20function%20and%20engraftment&author=Z.%20Ju&author=H.%20Jiang&author=M.%20Jaworski&author=C.%20Rathinam&author=A.%20Gompf&volume=13&publication_year=2007&pages=742-747&pmid=17486088&doi=10.1038/nm1578&'s revenue stream
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res.&title=Levels%20of%20p53%20protein%20increase%20with%20maturation%20in%20human%20hematopoietic%20cells&author=M.B.%20Kastan&author=A.I.%20Radin&author=S.J.%20Kuerbitz&author=O.%20Onyekwere&author=C.A.%20Wolkow&volume=51&publication_year=1991&pages=4279-4286&pmid=1868448&?
• Learn how profitable https://doi.org/10.1038/366461a0 is on a monthly basis
• How much does https://scholar.google.com/scholar_lookup?journal=Nature.&title=A%20C.%20elegans%20mutant%20that%20lives%20twice%20as%20long%20as%20wild%20type&author=C.%20Kenyon&author=J.%20Chang&author=E.%20Gensch&author=A.%20Rudner&author=R.%20Tabtiang&volume=366&publication_year=1993&pages=461-464&pmid=8247153&doi=10.1038/366461a0& net monthly?
• How much revenue does https://doi.org/10.1038/nature06115 bring in?
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Nature.&title=Haematopoietic%20stem%20cells%20do%20not%20asymmetrically%20segregate%20chromosomes%20or%20retain%20BrdU&author=M.J.%20Kiel&author=S.%20He&author=R.%20Ashkenazi&author=S.N.%20Gentry&author=M.%20Teta&volume=449&publication_year=2007&pages=238-242&pmid=17728714&doi=10.1038/nature06115&?
• How much does https://doi.org/10.1093/gerona/50A.2.B78 bring in each month?
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• What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cell.&title=Identification%20of%20clonogenic%20common%20lymphoid%20progenitors%20in%20mouse%20bone%20marrow&author=M.%20Kondo&author=I.L.%20Weissman&author=K.%20Akashi&volume=91&publication_year=1997&pages=661-672&pmid=9393859&doi=10.1016/S0092-8674(00)80453-5&?
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• What are the earnings of https://doi.org/10.1083/jcb.201010131?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol.&title=Manifestations%20and%20mechanisms%20of%20stem%20cell%20aging&author=L.%20Liu&author=T.A.%20Rando&volume=193&publication_year=2011&pages=257-266&pmid=21502357&doi=10.1083/jcb.201010131& produce monthly?
• What's the income of https://doi.org/10.1016/j.stem.2008.11.006?
• Earnings of https://scholar.google.com/scholar_lookup?journal=Cell%20Stem%20Cell.&title=p53%20regulates%20hematopoietic%20stem%20cell%20quiescence&author=Y.%20Liu&author=S.E.%20Elf&author=Y.%20Miyata&author=G.%20Sashida&author=Y.%20Liu&volume=4&publication_year=2009&pages=37-48&pmid=19128791&doi=10.1016/j.stem.2008.11.006&
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• How profitable is https://scholar.google.com/scholar_lookup?journal=J.%20Invest.%20Dermatol.&title=Effects%20of%20caloric%20restriction%20on%20skin%20and%20hair%20growth%20in%20mice&author=L.A.%20Loewenthal&author=W.%20Montagna&volume=24&publication_year=1955&pages=429-433&pmid=14367935&doi=10.1038/jid.1955.58&?
• What's the monthly income of https://doi.org/10.1016/j.cmet.2013.12.008?
• Check the income stats for https://scholar.google.com/scholar_lookup?journal=Cell%20Metab.&title=Fasting:%20molecular%20mechanisms%20and%20clinical%20applications&author=V.D.%20Longo&author=M.P.%20Mattson&volume=19&publication_year=2014&pages=181-192&pmid=24440038&doi=10.1016/j.cmet.2013.12.008&
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• What's the profit of https://doi.org/10.1146/annurev.nutr.25.050304.092526?
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• What's the income generated by https://doi.org/10.1042/CS20110340 each month?
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• What is the earnings of https://doi.org/10.1016/0014-4800(88)90059-7?
• Financial intake of https://scholar.google.com/scholar_lookup?journal=Exp.%20Mol.%20Pathol.&title=Involution%20of%20thymic%20epithelium%20and%20low%20serum%20thymulin%20bioactivity%20in%20weanling%20mice%20subjected%20to%20severe%20food%20intake%20restriction%20or%20severe%20protein%20deficiency&author=A.%20Mittal&author=B.%20Woodward&author=R.K.%20Chandra&volume=48&publication_year=1988&pages=226-235&pmid=3350144&doi=10.1016/0014-4800(88)90059-7&
• https://doi.org/10.1016/S1534-5807(02)00201-0 income
• How much does https://scholar.google.com/scholar_lookup?journal=Dev.%20Cell.&title=Myeloid%20or%20lymphoid%20promiscuity%20as%20a%20critical%20step%20in%20hematopoietic%20lineage%20commitment&author=T.%20Miyamoto&author=H.%20Iwasaki&author=B.%20Reizis&author=M.%20Ye&author=T.%20Graf&volume=3&publication_year=2002&pages=137-147&pmid=12110174&doi=10.1016/S1534-5807(02)00201-0& generate monthly?
• What's the revenue for https://doi.org/10.1038/nm0996-1011?
• How much does https://scholar.google.com/scholar_lookup?journal=Nat.%20Med.&title=The%20aging%20of%20hematopoietic%20stem%20cells&author=S.J.%20Morrison&author=A.M.%20Wandycz&author=K.%20Akashi&author=A.%20Globerson&author=I.L.%20Weissman&volume=2&publication_year=1996&pages=1011-1016&pmid=8782459&doi=10.1038/nm0996-1011& earn?
• Get to know https://doi.org/10.1182/blood-2003-10-3448's earnings
• How much money does https://scholar.google.com/scholar_lookup?journal=Blood.&title=Myeloid-biased%20hematopoietic%20stem%20cells%20have%20extensive%20self-renewal%20capacity%20but%20generate%20diminished%20lymphoid%20progeny%20with%20impaired%20IL-7%20responsiveness&author=C.E.%20Muller-Sieburg&author=R.H.%20Cho&author=L.%20Karlsson&author=J.F.%20Huang&author=H.B.%20Sieburg&volume=103&publication_year=2004&pages=4111-4118&pmid=14976059&doi=10.1182/blood-2003-10-3448& generate?
• How much does https://doi.org/10.1073/pnas.96.26.14943 gross monthly?
• Profit of https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA.&title=Constitutive%20Bcl-2%20expression%20throughout%20the%20hematopoietic%20compartment%20affects%20multiple%20lineages%20and%20enhances%20progenitor%20cell%20survival&author=S.%20Ogilvy&author=D.%20Metcalf&author=C.G.%20Print&author=M.L.%20Bath&author=A.W.%20Harris&volume=96&publication_year=1999&pages=14943-14948&pmid=10611317&doi=10.1073/pnas.96.26.14943&
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• What's the revenue for https://scholar.google.com/scholar_lookup?journal=FEBS%20Lett.&title=Calorie%20restriction%20and%20prevention%20of%20age-associated%20chronic%20disease&author=D.%20Omodei&author=L.%20Fontana&volume=585&publication_year=2011&pages=1537-1542&pmid=21402069&doi=10.1016/j.febslet.2011.03.015&?
• How much does https://doi.org/10.1038/nrg2269 pull in?
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• What's the financial outcome of https://doi.org/10.1084/jem.20050967?
• How profitable is https://scholar.google.com/scholar_lookup?journal=J.%20Exp.%20Med.&title=Global%20analysis%20of%20proliferation%20and%20cell%20cycle%20gene%20expression%20in%20the%20regulation%20of%20hematopoietic%20stem%20and%20progenitor%20cell%20fates&author=E.%20Passegu%C3%A9&author=A.J.%20Wagers&author=S.%20Giuriato&author=W.C.%20Anderson&author=I.L.%20Weissman&volume=202&publication_year=2005&pages=1599-1611&pmid=16330818&doi=10.1084/jem.20050967&?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Blood.&title=Administration%20of%20interleukin-6%20stimulates%20multilineage%20hematopoiesis%20and%20accelerates%20recovery%20from%20radiation-induced%20hematopoietic%20depression&author=M.L.%20Patchen&author=T.J.%20MacVittie&author=J.L.%20Williams&author=G.N.%20Schwartz&author=L.M.%20Souza&volume=77&publication_year=1991&pages=472-480&pmid=1991164& generate?
• What's the monthly income of https://doi.org/10.1177/0148607192016006561?
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• How much cash flow does https://scholar.google.com/scholar_lookup?journal=J.%20Exp.%20Med.&title=Early%20lymphocyte%20expansion%20is%20severely%20impaired%20in%20interleukin%207%20receptor-deficient%20mice&author=J.J.%20Peschon&author=P.J.%20Morrissey&author=K.H.%20Grabstein&author=F.J.%20Ramsdell&author=E.%20Maraskovsky&volume=180&publication_year=1994&pages=1955-1960&pmid=7964471&doi=10.1084/jem.180.5.1955& have monthly?
• How much income is https://doi.org/10.1016/j.stem.2007.10.008 earning monthly?
• Get to know https://scholar.google.com/scholar_lookup?journal=Cell%20Stem%20Cell.&title=Critical%20role%20of%20thrombopoietin%20in%20maintaining%20adult%20quiescent%20hematopoietic%20stem%20cells&author=H.%20Qian&author=N.%20Buza-Vidas&author=C.D.%20Hyland&author=C.T.%20Jensen&author=J.%20Antonchuk&volume=1&publication_year=2007&pages=671-684&pmid=18371408&doi=10.1016/j.stem.2007.10.008&'s earnings
• What are the earnings of https://doi.org/10.1016/j.cmet.2010.11.015?
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• How much does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA.&title=Cell%20intrinsic%20alterations%20underlie%20hematopoietic%20stem%20cell%20aging&author=D.J.%20Rossi&author=D.%20Bryder&author=J.M.%20Zahn&author=H.%20Ahlenius&author=R.%20Sonu&volume=102&publication_year=2005&pages=9194-9199&pmid=15967997&doi=10.1073/pnas.0503280102& pull in monthly?
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